acquired platelet function defect

Any non-hereditary defect in platelet function.

Clinical findings
Defective coagulation, easy bruising, bleeding gums, nosebleeds, vaginal bleeding, rectal bleeding, haematemesis, epistaxis, haematuria.

Aetiology
Polycythemia vera, leukaemia, myelofibrosis, renal failure, multiple myeloma, drugs—penicillins, salicylates, phenothiazines.

Diagnosis
Bleeding time, PT, PTT, platelet count.

acquired platelet function defect

Acquired qualitative platelet disorders Hematology Any non-hereditary defect in platelet function Etiology Polycythemia vera, leukemia, myelofibrosis, renal failure, multiple myeloma, drugs–penicillins, salicylates, phenothiazines Clinical Defective coagulation, easy bruising, bleeding gums, nosebleeds, vaginal bleeding, rectal bleeding, hematemesis, epistaxis, hematuria Diagnosis Bleeding time, PT, PTT, platelet count

Mentioned in ?

References in periodicals archive ?

Acquired platelet function defect may result from oxidative stress.

CD40 ligand and P-selectin in heterozygous Beta-thalassemia

A review of the indications for platelet transfusions administered to patients with platelet counts in the reference interval over the first 4.5 months after discontinuation of the BT test revealed only cardiopulmonary bypass as an indication related to a known, acquired platelet function defect. BT tests had not historically been ordered for this group of patients before discontinuation of the test.

Discontinuation of the bleeding time test without detectable adverse clinical impact