Evaluation and management of acquired methemoglobinemia
associated with topical benzocaine use.
A large number of agents are known to cause the development of acquired methemoglobinemia with most implicated examples being sulfonamides, local anesthetic drugs, and nitrate-containing vegetables (5).
As a local anesthetic, prilocaine is more frequently encountered as a cause of acquired methemoglobinemia in newborns and children compared to adults.
Both chemicals (such as aniline dyes, pesticides, and fava beans) and medications (including dapsone, nitrous oxide, and quinine-based antimalaria drugs) can cause acquired methemoglobinemia
: a retrospective series of 138 cases at 2 teaching hospitals.
I would like to add to this well written article that we have also reported acquired methemoglobinemia
cases with administration of cytanest in puerperal women with G6PD deficiency and infants in whom erythrocyte cytochrome 65 reductase was assoyed (1-4), which is the main enzyme for methemoglobin reductase in erythrocytes as mentioned by the authors.
When patients become cyanotic: acquired methemoglobinemia
. J Am Dent Assoc 1999;130:826-831.
Drugs that cause acquired methemoglobinemia
are prevalent in both the hospital and the outpatient setting.
What are the other causes of acquired methemoglobinemia
Objective: This study aimed to determine the etiologic factors of acquired methemoglobinemia
in infants younger than three months in our region.
Treatment of high-risk, refractory acquired methemoglobinemia
with automated red cell blood cell exchange.
(3) reviewed 138 acquired methemoglobinemia
cases, of which 42% were caused by dapsone, followed by benzocaine (4%) and primaquine (4%).