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com·mon var·i·a·ble im·mu·no·de·fi·cien·cy (CVI),[MIM*240500]
immunodeficiency of unknown cause, and usually unclassifiable; usual onset after age 15 years but may occur at any age in either sex; the total quantity of immunoglobulin is commonly less than 300 mg/dL; the number of B lymphocytes is often within normal limits but there is a lack of plasma cells in lymphoid tissue; cellular (T-lymphocyte) immunity is usually intact; there is an increased susceptibility to pyogenic sinopulmonary infection and often autoimmune disease.
Etymology: L, acquirere, to obtain; Gk, hypo, a deficiency, gamma, third letter of Greek alphabet; L, globulus, small globe; Gk, haima, blood
an acquired deficiency of the gamma globulin blood fraction. See also hypogammaglobulinemia.
Immunoglobulin deficiency caused by another illness, such as the loss of immunoglobulins in the urine in nephrotic syndrome, or in the stool, in patients with malabsorption.
See also: hypogammaglobulinemia