The most common clinical manifestation of dermatologic toxicity is an acneiform
, or papulopustular, rash marked by eruptions characterized as "acne-like" pustules with monotonous lesion morphology (FIGURE 1 A).
More commonly, however, Demodex is a secondary player in pediatric acneiform
rashes, including periorbital dermatitis, steroid dermatitis, mid-childhood acne, and rosacea.
The mean total acneiform
lesion count increased from 2.7 at baseline to 13.4 on day 4 and to 18.2 on day 7.
The skin lesions resolve with pock-like or acneiform
scarring, usually on the face and distal extremities.
Pertinent physical examination findings included facial acneiform
lesions, moon facies, and supraclavicular fullness.
The onset of symptoms presented anywhere from 3-4 days of initiation of azathioprine, with 49% of patients exhibiting cutaneous findings suggesting a drug-induced acneiform
and folliculitis eruption .
Conventional chemotherapy and targeted or immunotherapy that are thought to be well tolerated and may cause various cutaneous adverse reactions ranging from nonlife-threatening skin toxicities such as paronychia, acneiform
eruption, and alopecia to life-threatening severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).
###papulopustular lesions, acneiform
nodules) found in
Two cases of acneiform
eruption associated with lamotrigine.
An unusual papular and acneiform
eruption in the Negro child.
Cutaneous adverse reactions associated with targeted anticancer therapies commonly manifest as acneiform
eruption, hand-foot skin reaction, paronychia, skin fissures, and dermal hypersensitivity reaction .
A skin biopsy was done and it revealed disrupted follicles with surrounding mixed suppurative and granulomatous dermatitis most suggestive of acneiform
processes including ruptured folliculitis and rosacea.