In in vitro studies SPINK1 has been shown to stimulate proliferation and colony formation of cells derived from a rat pancreatic acinar cell tumor
Solid and cystic acinar cell tumor
of the pancreas: a tumor in young women with favourable prognosis.
It has been known under different names such as solid-pseudopapillary tumor, papillary epithelial neoplasm, papillary cystic neoplasm, solid and papillary epithelial neoplasm, solid and cystic acinar cell tumor
, papillary and solid neoplasm, papillary-cystic epithelial neoplasm, papillary-cystic carcinoma, solid and papillary neoplasm, papillary cystic tumor, solid and cystic tumor, solid and papillary neoplasm, low-grade papillary neoplasm, Hamoudi tumor, and Frantz tumor, (1) but the current term, solid-pseudopapillary neoplasm, enjoyed the widest acceptance and has been retained in the latest World Health Organization classification.
Several variants of acinar cell tumors
have been described: 1) acinar cell cystadenocarcinoma 2) mixed acinar endocrine tumor 3) mixed acinar ductal carcinoma and 4) a rare tumor combining ductal, acinar and islet cell components.
However, collection of materials for the creation of a cell block is typically performed for potential diagnostic immunohistochemistry that may be used in difficult cases with uncommon tumors, such as neuroendocrine or acinar cell tumors
Yet in the TCDD, PCB-126, PeCDF, and TEF-mixture groups, we found four, four, four, and five pancreatic acinar cell tumors, respectively, including two or more carcinomas in each study.
degeneration and inflammation) in the exocrine pancreas of treated animals with acinar cell tumors did not indicate a higher grade of severity compared with other animals in the same groups without such tumors.
GSK and XenoPort are currently evaluating the Complete Response letter, in which the FDA indicated that a preclinical finding of pancreatic acinar cell tumors
in rats was of sufficient concern to preclude approval of Horizant for RLS at this time.