Transmission electron micrograph of parotid salivary gland of 30 cm CVRL (141st day) buffalo foetus showing appearance of medium electron dense secretory granules (SG) in the acinar cells
Immunohistochemically, acinar cell
carcinomas are positive, with different frequencies, for trypsin, chymotrypsin, BCL10, and lipase.
In the normal state these enzymes are synthesized in pancreatic acinar cells
as inactive pro-enzymes (such as trypsinogen) and are maintained in this state until activated by enterokinase upon entry into the gut lumen.
The UPR is critical for efficient functioning of the endoplasmic reticulum (ER) in the pancreatic acinar cell
, because the ER provides for the synthesis of cellular components necessary for transporting digestive enzymes manufactured in ER to zymogen granules for storage and for secretion.
31] revealed alleviation of pathological changes by lycopene pretreatment including protection against necrosis and apoptosis in acinar cells
which was maintained by relieving the mitochondrial and endoplasmic stress, decreased levels of TNF-[alpha], serum amylase, C-reactive protein, MDA and lipid peroxidation, and also heightened SOD state.
Clinical characterististics and outcomes from an institutional series of acinar cell
carcinoma of the pancreas and related tumours.
3]H]arachidonic acid, we demonstrated that the stimulatory effect of the LPS on the acinar cell
arachidonic acid release was susceptible to inhibition by MAFP, a specific inhibitor of cPL[A.
In vitro work has shown that the FAEE palmitoleic acid ethyl ester induces a significant increase of calcium in the substance filling the acinar cell
001): the increasing trend in pancreatic acinar cell
adenoma/carcinoma in the TCDD study.
The acinar cells
secrete pancreatic juices--water containing salts and enzymes--that flow from small ducts into the main pancreatic ducts and eventually empty into the duodenum to aid digestion.
The FDA indicated that a preclinical finding of pancreatic acinar cell
tumors in rats was of sufficient concern to preclude approval of the Horizant NDA for RLS in its current form.
Histologically, acinar cell
carcinoma consists of acinar, trabecular, or solid proliferations of uniform tumor cells with diffuse granular cytoplasm.