acinar adenocarcinoma


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acinar adenocarcinoma

acinic cell carcinoma

Breast
An extremely rare carcinoma that is morphologically identical to the same-named tumours of the salivary glands. There is little known about their behaviour, but they do metastasise to regional lymph nodes and may be fatal.

DiffDx
Microglandular adenosis, apocrine carcinoma.

Oral
A usually low-grade, slowly growing salivary (80% are parotid) gland carcinoma with serous acinar cell differentiation. It comprises 1% to 6% of salivary gland tumours, and 10% to 17% of all salivary gland malignancies. In some series it is more common in females, in others, men; it peaks in the 5th decade; 3% are bilateral.

Risk factors
Radiation exposure, familial predisposition, wood dust inhalation.
 
Staging
Outcomes are worse with larger tumours, incomplete excision, deep lobe involvement and MIB proliferation index of > 10%.
 
Prognosis
5-year survival, 90%; 20-year-survival, 55%; 12–35% recur, 8% metastasise.

Poor prognosticators.

Pain at presentation, fixation of tissue to other structures, gross invasion, focal necrosis, perineural invasion, histologic features: desmoplasia, atypia/pleomorphism, increased mitotic activity.  Prognosis is better if the tumour nodules are well-circumscribed, microcystic and have lymphoid follicles.

Management
Usually wide local excision suffices; complete first-time surgical excision is critical to cure.

acinar adenocarcinoma

Adenocarcinoma in which the cells are in the shape of alveoli. Synonym: alveolar adenocarcinoma
See also: adenocarcinoma
References in periodicals archive ?
15) Due to the non-targeted nature of TRUS guidance and because ductal adenocarcinoma typically only represents a small proportion of the tumour composed mainly of acinar adenocarcinoma, areas of ductal cancer can easily be missed.
Pathologic stage of prostatic ductal adenocarcinoma at radical prostatectomy: Effect of percentage of the ductal component and associated grade of acinar adenocarcinoma.
The ductal component coexisted with conventional acinar adenocarcinoma in all ductal cases.
Our study demonstrated that characterization of prostatic ductal and acinar adenocarcinoma relied mainly on pathological and immunohistochemical examination.
8% of prostate adenocarcinoma and is frequently admixed with high-grade prostatic acinar adenocarcinoma.
To our knowledge, this is the first reported case of prostatic acinar adenocarcinoma with micropapillary architecture.
8) These findings support a diagnosis of a pure prostatic acinar adenocarcinoma with micropapillary features.
Features seen within PTAT that create difficulty in distinguishing it from prostatic acinar adenocarcinoma include the following: (1) crowded and sometimes disorganized patterns of growth, (2) relatively high nuclear to cytoplasmic ratio with slightly enlarged nuclei, (3) straight luminal borders in some glands, (4) the presence of visible but small nucleoli, (5) negative staining of some glands for basal cells markers, and (6) positive staining of some glands for racemase (Figures 1, A through F, and 2, A through F).
Partial atrophy differs from atrophic acinar adenocarcinoma in that atrophic cancers have one or more of the following features: (1) a more-infiltrative appearance, where the cancer glands infiltrate as isolated glands between benign glands; (2) associated nonatrophic cancer; or (3) prominent cytologic atypia beyond what can be seen in benign atrophy.
However, a variant of acinar adenocarcinoma, termed pseudohyperplastic carcinoma (48) (Figure 11, B through D), can, especially on lower-power magnification, look very much like such benign hyperplastic glands even in needle biopsy material.
Although loss of chromosomes 8p and 12p has been reported in conventional acinar adenocarcinoma, (27,28) a normal karyotype has been found in basal cell tumors using comparative genomics hybridization.
The main differential diagnoses of adenoid cystic/basal cell carcinoma of the prostate include benign basal cell hyperplasia and cribriform pattern of acinar adenocarcinoma.