acinar adenocarcinoma


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acinic cell carcinoma

Breast
An extremely rare carcinoma that is morphologically identical to the same-named tumours of the salivary glands. There is little known about their behaviour, but they do metastasise to regional lymph nodes and may be fatal.

DiffDx
Microglandular adenosis, apocrine carcinoma.

Oral
A usually low-grade, slowly growing salivary (80% are parotid) gland carcinoma with serous acinar cell differentiation. It comprises 1% to 6% of salivary gland tumours, and 10% to 17% of all salivary gland malignancies. In some series it is more common in females, in others, men; it peaks in the 5th decade; 3% are bilateral.

Risk factors
Radiation exposure, familial predisposition, wood dust inhalation.
 
Staging
Outcomes are worse with larger tumours, incomplete excision, deep lobe involvement and MIB proliferation index of > 10%.
 
Prognosis
5-year survival, 90%; 20-year-survival, 55%; 12–35% recur, 8% metastasise.

Poor prognosticators.

Pain at presentation, fixation of tissue to other structures, gross invasion, focal necrosis, perineural invasion, histologic features: desmoplasia, atypia/pleomorphism, increased mitotic activity.  Prognosis is better if the tumour nodules are well-circumscribed, microcystic and have lymphoid follicles.

Management
Usually wide local excision suffices; complete first-time surgical excision is critical to cure.

acinar adenocarcinoma

Adenocarcinoma in which the cells are in the shape of alveoli. Synonym: alveolar adenocarcinoma
See also: adenocarcinoma
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References in periodicals archive ?
(15) Due to the non-targeted nature of TRUS guidance and because ductal adenocarcinoma typically only represents a small proportion of the tumour composed mainly of acinar adenocarcinoma, areas of ductal cancer can easily be missed.
Pathologic stage of prostatic ductal adenocarcinoma at radical prostatectomy: Effect of percentage of the ductal component and associated grade of acinar adenocarcinoma. AmJ Surg Pathol 2011;35:615-9.
Our study demonstrated that characterization of prostatic ductal and acinar adenocarcinoma relied mainly on pathological and immunohistochemical examination.
Finally, the cases of ductal carcinoma were limited in number and all ductal cases we examined showed more than 60% of the ductal component, thus we could not determine whether cases containing a lesser volume of ductal component showed more advanced pathological features compared to acinar adenocarcinoma.
(49) Its behavior is analogous to that of GS 6 acinar adenocarcinoma, and it should be distinguished from its aggressive conventional ductal adenocarcinoma counterpart.
Intraductal carcinoma of the prostate may be misdiagnosed as cribriform acinar adenocarcinoma and assigned a GS, where in fact IDC-P is regarded as a late presentation of high-grade invasive carcinoma growing within preexisting glands/ducts, and not an invasive adenocarcinoma in and of itself.
Prostatic ductal adenocarcinoma, an aggressive form of prostate adenocarcinoma, accounts for 0.4% to 0.8% of prostate adenocarcinoma and is frequently admixed with high-grade prostatic acinar adenocarcinoma. (3, 31, 32) Prostatic ductal adenocarcinoma can arise both in large periurethral and peripheral prostatic ducts.
To our knowledge, this is the first reported case of prostatic acinar adenocarcinoma with micropapillary architecture.
Partial atrophy differs from atrophic acinar adenocarcinoma in that atrophic cancers have one or more of the following features: (1) a more-infiltrative appearance, where the cancer glands infiltrate as isolated glands between benign glands; (2) associated nonatrophic cancer; or (3) prominent cytologic atypia beyond what can be seen in benign atrophy.
However, a variant of acinar adenocarcinoma, termed pseudohyperplastic carcinoma (48) (Figure 11, B through D), can, especially on lower-power magnification, look very much like such benign hyperplastic glands even in needle biopsy material.
Cytology.--The only cytology specimen in the nonresponder group was a fine-needle aspiration of the lung where the tumor was considered to be an acinar adenocarcinoma.
Staining for PSA is usually negative, (23,24,26) but in some cases positivity with this marker has been reported, especially in cases in association with concomitant acinar adenocarcinoma or inflammation.