acidified serum test


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia.

a·cid·i·fied se·rum test

lysis of the patient's red blood cells in acidified fresh serum, specific for paroxysmal nocturnal hemoglobinuria.
Synonym(s): Ham test
A test that assesses susceptibility of erythrocytes to hemolysis, which is markedly increased in paroxysmal nocturnal hemoglobinuria (PNH); see there.
Principle In acidified serum, complement is activated by the alternate pathway, binds to RBCs, and lyses PNH cells which are sensitive to complement activation; positive Ham test also occurs in the rare congenital dyserythropoietic anemia type II, also known as HEMPAS

a·cid·i·fied se·rum test

(ă-sid'i-fīd sēr'ŭm test)
Lysis of the patient's red blood cells in acidified fresh serum, specific for paroxysmal nocturnal hemoglobinuria.
Synonym(s): Ham test.

Ham,

Thomas Hale, U.S. physician, 1905–.
Ham test - lysis of the patient's red cells in acidified fresh serum. Synonym(s): acidified serum test