The goat had low body score, hyporexia, alopecia, achromotrichia (markedly around the eyes) and in the neurologic assessment presented stiff and unbalanced gait, left hindlimb protraction, paralysis with dragging of digit and difficulty to stand up (Figure 1A, 1B and 1C).
In copper-deficient ruminants, a wide variation in the clinical signs of adult animals could be observed, including anemia, weight loss, achromotrichia, alopecia, and diarrhea at the onset of clinical signs (TOKARNIA et al., 1998; SOUSA et al., 2017).
Vitiligo is a common, acquired, primary melanocytopenia of unknown aetiology, clinically characterised by well-defined milky white depigmented macules with variable achromotrichia without any change in texture and histologically by degeneration and disappearance of melanocytes in the involved skin, not infrequently in pigment epithelium of the eyes, leptomeninges and inner ear.
Segmental pattern and achromotrichia have more predilection for children as seen in our study.
SkQs prolonged life of different organisms , helped animals to survive after brain and kidney ischemia , stroke, and heart attack , and decelerated the development of many age-related pathological states, such as cataract and some other eye diseases, balding, achromotrichia
, lordokyphosis, and myeloid shift of the blood .
The exact mechanism of depigmentation of skin includes breakdown in conversion of tyrosine to melanin because of reduced tyrosinase activity resulting in achromotrichia and leukoderma in copper deficiency (Underwood, 1977).
The characteristic clinical finding were graying of hair (achromotrichia) on various parts of body at initial stages followed by depigmentation of skin.