achlorhydria


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achlorhydria

 [a″klor-hi´dre-ah]
absence of hydrochloric acid from gastric juice; associated with pernicious anemia, stomach cancer, and pellagra. adj., adj achlorhy´dric.

a·chlor·hy·dri·a

(ā-klōr-hī'drē-ă),
Absence of hydrochloric acid from the gastric juice.
[G. a- priv. + chlorhydric (acid)]

achlorhydria

(ā′klôr-hī′drē-ə)
n.
Absence of hydrochloric acid in the gastric secretions of the stomach.

a·chlor·hy′dric (-drĭk) adj.

achlorhydria

A condition characterised by an absence of HCl in gastric juice; formally,
(1) a peak acid output in response to a maximally effective stimulus that results in an intragastric pH of > 5.09 in men and > 6.81 in women; or
(2) a maximal acid output of < 6.9 m/mole/h in men and < 5.0 m/mole/h in women; or
(3) a ratio of serum pepsinogen I/pepsinogen II of < 2.9.
 
Associations
Gastric cancer, hip fracture, bacterial overgrowth.

Aetiology
Antiparietal cell antibodies, chronic Helicobacter pylori infection, protein-pump inhibitor therapy.

achlorhydria

Absence of HCl in gastric juice

a·chlor·hy·dri·a

(ā-klōr-hī'drē-ă)
Absence of hydrochloric acid from the gastric juice.
[G. a- priv. + chlorhydric (acid)]

achlorhydria

Absence of the normal hydrochloric acid in the stomach as a result of wasting (atrophy) of the acid-secreting cells in the lining. Achlorhydria is commonly found in PERNICIOUS ANAEMIA when autoimmune damage to the stomach lining is associated with loss of secretion of an intrinsic factor in the stomach that leads to failure of vitamin B12 absorption.

Achlorhydria

An abnormal condition in which hydrochloric acid is absent from the secretions of the gastric glands in the stomach.

a·chlor·hy·dri·a

(ā-klōr-hī'drē-ă)
Absence of hydrochloric acid from the gastric juice.
[G. a- priv. + chlorhydric (acid)]
References in periodicals archive ?
The definite treatment for watery diarrhea, hypokalemia and achlorhydria syndrome is removal of the tumor, if possible.
(54) These tumors are characterized by the secretion of vasoactive intestinal peptide, which produces the Verner-Morrison syndrome (watery diarrhea, hypokalemia, achlorhydria).
It is interesting to note that Rhodes (1976) describes a patient suffering from achlorhydria. After ingestion of enteric coated PO the patient complained of heartburn and eructation; investigations demonstrated that the capsule disintegrated in the stomach due to the high pH.
(4)The conditions that define the high-risk groups include alcoholism, liver disease, cancer, diabetes, kidney disease, steroid dependency, AIDS, chronic intestinal disease, achlorhydria, and hemochromatosis/hemosiderosis.
Functional PanNETs (F-PanNETs) comprehend insulinomas (35-40% of F-PanNETs) manifesting with the classical Whipple's triad (fasting hypoglycemia, symptoms of hypoglycemia, and immediate relief of symptoms after the administration of glucose) [12], gastrinomas (16-30%) with the Zollinger-Ellison syndrome (multiple peptic ulcers, esophageal reflux, and diarrhea), glucagonomas (<10%) with the "4D syndrome" (dermatitis, diabetes, deep vein thrombosis, and depression), and VIPomas (<10%) related to the Verner-Morrison syndrome (watery diarrhea, achlorhydria, and hypokalemia).
Misleading alkaline pH in the stomach can be seen in case of achlorhydria and with the use of potent anti-acid drugs.
Other common underlying conditions are atherosclerosis, diabetes, collagen diseases, liver cirrhosis, and achlorhydria. Our patient was not found to have any of those predisposing factors.
A Case Report on the Successful Use of Inositol Hexaniacinate for the Treatment of Achlorhydria: Its Possible Mechanism of Action Upon the Central Nervous System and Parietal Cell-Adenosine Triphosphate-Dependent K+/H+ Pump, by Jonathan E.
More than 80% of patients with septicemia have one or more chronic medical conditions, including kidney disease, diabetes, cancer, hematologic disorders, achlorhydria, or most commonly, liver disease due to alcohol or hepatitis C virus infection.
H pylori impairs the normal secretion of hydrochloric acid, provoking achlorhydria in infected patients3.
Achlorhydria does not protect against benign upper gastrointestinal ulcers during NSAID use.