acetylcholinesterase inhibitors

Drugs that block the action of the enzyme ACETYLCHOLINESTERASE which quickly breaks down the neurotransmitter acetylcholine. This neurotransmitter is the linking agent between nerve cells in the outer layer (cortex) of the brain. The early impairment of cognitive function found in a common forms of dementia known as dementia with Lewy bodies (DLB) is associated with a reduction in acetylcholine levels. These drugs, by inhibiting, acetylcholine breakdown, have been found helpful in reducing the severity of the early stages of dementia. They cannot be expected to cure or even delay progress of the dementia. The drug group includes DONEPEZIL, GALANTAMINE and RIVASTIGMINE.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Mentioned in ?

References in periodicals archive ?

Acetylcholinesterase Inhibitors: Pharmacology and toxicology.

A Comparative Study of Inhibitory Properties of Saponins (derived from Azadirachta indica) for Acetylcholinesterase of Tribolium castaneum and Apis mellifera

High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products.

In Vitro Protection by Crataegus microphylla Extracts Against Oxidative Damage and Enzyme Inhibition Effects/Crataegus microphylla Ekstrelerinin Oksidatif Hasara Karsi In Vitro Koruma ve Enzim Inhibisyonu Etkileri

Verpoorte, "Screening for acetylcholinesterase inhibitors from Amaryllidaceae using silica gel thin-layer chromatography in combination with bioactivity staining," Journal of Chromatography A, vol.

Bioactivity and Toxicity of Senna cana and Senna pendula Extracts

Yirmiya, "Acetylcholinesterase inhibitors reduce brain and blood interleukin-1[beta] production," Annals of Neurology, vol.

Effect of Essential Oils from Ginger (Zingiber officinale) and Turmeric (Curcuma longa) Rhizomes on Some Inflammatory Biomarkers in Cadmium Induced Neurotoxicity in Rats

Treatment with acetylcholinesterase inhibitors may lead to bradycardia by potentiating cardiac vagal activity [20].

Electrocardiogram Changes of Donepezil Administration in Elderly Patients with Ischemic Heart Disease

Yirmiya, "Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production," Annals of Neurology, vol.

Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation

Villalobos et al., "Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease," European Journal of Pharmacology, vol.

Acetylcholinesterase Inhibitors Assay Using Colorimetric pH Sensitive Strips and Image Analysis by a Smartphone

Shidu Yan, "Acetylcholinesterase inhibitors: structure based design, synthesis pharmacophore modeling, and virtual screening," Journal of Chemical Information and Modelling, vol.

Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

Pohanka, "Acetylcholinesterase inhibitors: a patent review (2008 present)," Expert Opinion on Therapeutic Patents, vol.

Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase

Li, "Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors," Bioorganic & Medicinal Chemistry, vol.

Synthesis and Biological Evaluation of Novel Jatrorrhizine Derivatives with Amino Groups Linked at the 3-Position as Inhibitors of Acetylcholinesterase

Reversible acetylcholinesterase inhibitors are used as initial treatment for MG and pyridostigmine is the most widely used drug.

Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis Successfully Treated with Hyoscyamine

TLC bioautographic method has been modified to detect acetylcholinesterase inhibitors. In this method TLC plate and 1- naphthyl acetate were used as a substrate.

Synthesis of Bromo Phenyl Piperidine Derivatives and the Study of their Effects on Neurotransmitters and Strong Compatibility with Alpha Amylase Enzyme