acetylcholinesterase inhibitors

Drugs that block the action of the enzyme ACETYLCHOLINESTERASE which quickly breaks down the neurotransmitter acetylcholine. This neurotransmitter is the linking agent between nerve cells in the outer layer (cortex) of the brain. The early impairment of cognitive function found in a common forms of dementia known as dementia with Lewy bodies (DLB) is associated with a reduction in acetylcholine levels. These drugs, by inhibiting, acetylcholine breakdown, have been found helpful in reducing the severity of the early stages of dementia. They cannot be expected to cure or even delay progress of the dementia. The drug group includes DONEPEZIL, GALANTAMINE and RIVASTIGMINE.

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The pesticides here are known acetylcholinesterase inhibitors, leading to increased levels of acetylcholine.

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It would be interesting to find out how dopamine agonists, acetylcholinesterase inhibitors, and other medications could be effective in treatment of apathy (as a primary condition or as a symptom of another disorder that does not remit after the original disorder has been treated).

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No approved treatment for DLB currently exists, although in Japan the use of acetylcholinesterase inhibitors is recommended in the treatment of the disease according to major consensus guidelines.

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Denepezil (Aricept): It belongs to the group of acetylcholinesterase inhibitors.

Prolong independency

The effectiveness and safety of the coadministration of memantine HCl extended release and acetylcholinesterase inhibitors (AChEIs), together with donepezil HCl, was based on the results of a randomized and double-blind, placebo-controlled study of 677 outpatients on a stable dose of AChEIs.

United States : FDA approval for Namzaric to treat dementia obtained by Actavis and Adamas

Acetylcholinesterase inhibitors are mostly a symptomatic treatment but some claims are made about a neuroprotective effect.

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The drugs, known as acetylcholinesterase inhibitors, block an enzyme involved in controlling the activity of a nerve message chemical.

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Huperzine A is proving to be one of the most potent and selective acetylcholinesterase inhibitors under study for the treatment of Alzheimer's disease, which damages memory and affects 4 million U.

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These therapies include the acetylcholinesterase inhibitors (AChEIs) donepezil (Eisai/Pfizer's Aricept, generics), galantamine (Ortho-McNeil Neurologic's Razadyne, Razadyne ER, generics), and rivastigmine (Novartis's Exelon, generics, and the Exelon patch) as well as the NMDA receptor antagonist memantine (Forest Laboratories' Namenda).

Research and Markets: Physician and Payer Insights on the Impact of Emerging Therapies and Generic Donepezil on the U.S. Alzheimer's Disease Market 2012