acetylcholinesterase


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Related to acetylcholinesterase: Acetylcholinesterase inhibitors

acetylcholinesterase

 [as″ĕ-til-ko″lin-es´ter-ās]
an enzyme present in nervous tissue, muscle, and red blood cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid. This enzyme is present throughout the body, but is particularly important at the myoneural junction, where the nerve fibers terminate. Acetylcholine is released when a nerve impulse reaches a myoneural junction. It diffuses across the synaptic cleft and binds to cholinergic receptors on the muscle fibers, causing them to contract. cholinesterase splits acetylcholine into its components, thus stopping stimulation of the muscle fibers. The end products of the metabolism of acetylcholine are taken up by nerve fibers and resynthesized into acetylcholine. The drugs neostigmine, physostigmine, and pyridostigmine inhibit acetylcholinesterase and are used to treat myasthenia gravis, a disease in which the cholinergic receptors are attacked by autoantibodies. The drug extends the effect of acetylcholine on the muscle fiber. Called also true cholinesterase

a·ce·tyl·cho·lin·es·ter·ase

(a-sĕ'til-kō'lin-es'ter-ās), [MIM*100740]
The cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (for example, motor endplates and autonomic ganglia).

acetylcholinesterase

/ac·e·tyl·cho·lin·es·ter·ase/ (AChE) (-ko″lĭ-nes´ter-ās) an enzyme present in the central nervous system, particularly in nervous tissue, muscle, and red cells, that catalyzes the hydrolysis of acetylcholine to choline and acetic acid.

acetylcholinesterase

(ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz′)
n.
An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of acetylcholine.

acetylcholinesterase (AChE)

[-kō′lines′tərās]
an enzyme present at the endings of voluntary nerves and parasympathetic involuntary nerves and autonomic nerve ganglia. It inactivates and prevents the accumulation of the neurotransmitter acetylcholine released during nerve impulse transmission by hydrolyzing the substance to choline and acetate. The action reduces or prevents excessive firing of neurons at neuromuscular junctions.

Acetylcholinesterase

A hydrolase in the membrane of postsynaptic cells which metabolises acetylcholine into choline and acetic acid in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impulse.
Location CNS, red cells, motor endplates

acetylcholinesterase

Neurophysiology A hydrolase that metabolizes acetylcholine to acetyl and choline in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impule; acetylcholinesterase is found in the CNS, RBCs, motor endplates

a·ce·tyl·cho·lin·es·ter·ase

(AChE) (as'ĕ-til-kō'lin-es'tĕr-ās)
One of a family of enzymes capable of catalyzing the hydrolysis of acetylcholine.

acetylcholinesterase

An ENZYME that rapidly inactivates ACETYLCHOLINE by breaking it down to acetic acid and choline. Also known as cholinesterase.

acetylcholinesterase

the enzyme present in the synaptic cleft that destroys acetylcholine (see END PLATE).

Acetylcholinesterase

An enzyme that breaks down acetylcholine.
Mentioned in: Insecticide Poisoning

acetylcholinesterase 

An enzyme that degrades and inactivates acetylcholine. This compound is mainly found in neurons and at neuromuscular junctions. Drugs that inhibit this enzyme (e.g. diisopropyl fluorophosphate, physostigmine, edrophonium, echothiophate, DFP) can be used in the diagnosis and possible treatment of myasthenia gravis as well as certain forms of esotropia and glaucoma. Syn. specific cholinesterase. See anticholinesterase drugs.

a·ce·tyl·cho·lin·es·ter·ase

(as'ĕ-til-kō'lin-es'tĕr-ās) [MIM*100740]
Cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (e.g., motor endplates and autonomic ganglia).

acetylcholinesterase

an enzyme present in nervous tissue, muscle and red cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid; called also true cholinesterase. Abbreviated AChE.

acetylcholinesterase antagonists
organophosphorus compounds and carbamates that act by inactivating acetylcholinesterase; hence poisoning by these compounds has parasympatheticomimetic manifestations.
References in periodicals archive ?
Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions.
Acetylcholinesterase inhibition in estuarine fish and invertebrates as an indicator of organophosphorus insecticide exposure and effects.
Characterization of acetylcholinesterase from the brain of the amazonian tambaqui (Colossoma macropomum) and in vitro effect of organophosphorus
However, none of the alkaloids detected in the extracts surprisingly correspond with any known acetylcholinesterase inhibitor within this class of compounds.
Acetylcholinesterase of Mytilus galloprovincialis Lmk: hemolymph: a suitable environmental biomarker.
The adhesive role of acetylcholinesterase (AChE): detection of AChE binding proteins in developing rat spinal cord.
All patients must have been taking an acetylcholinesterase inhibitor for at least 120 days prior to baseline.
Recognizing the need to rapidly sense nerve-damaging chemicals that could be released into public places, David Lawrence Vigliarolo Bauer of Hunter College High School in New York City designed a device that detects compounds that stop the enzyme acetylcholinesterase from working.
The research, described in the journal Phytotherapy Research, found that tea inhibits the activity of the enzymes acetylcholinesterase and butyrylcholinesterase, which have been found in the brains of Alzheimer's patients.
They found that both green and black tea inhibited the activity of the enzyme acetylcholinesterase (AChE), which breaks down the chemical messenger, or neurotransmitter, acetylcholine.

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