acetylcholinesterase


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Related to acetylcholinesterase: Acetylcholinesterase inhibitors

acetylcholinesterase

 [as″ĕ-til-ko″lin-es´ter-ās]
an enzyme present in nervous tissue, muscle, and red blood cells that catalyzes the hydrolysis of acetylcholine to choline and acetic acid. This enzyme is present throughout the body, but is particularly important at the myoneural junction, where the nerve fibers terminate. Acetylcholine is released when a nerve impulse reaches a myoneural junction. It diffuses across the synaptic cleft and binds to cholinergic receptors on the muscle fibers, causing them to contract. cholinesterase splits acetylcholine into its components, thus stopping stimulation of the muscle fibers. The end products of the metabolism of acetylcholine are taken up by nerve fibers and resynthesized into acetylcholine. The drugs neostigmine, physostigmine, and pyridostigmine inhibit acetylcholinesterase and are used to treat myasthenia gravis, a disease in which the cholinergic receptors are attacked by autoantibodies. The drug extends the effect of acetylcholine on the muscle fiber. Called also true cholinesterase

a·ce·tyl·cho·lin·es·ter·ase

(a-sĕ'til-kō'lin-es'ter-ās), [MIM*100740]
The cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (for example, motor endplates and autonomic ganglia).

acetylcholinesterase

(ə-sēt′l-kō′lə-nĕs′tə-rās′, -rāz′)
n.
An enzyme in the blood and in certain tissues that catalyzes the hydrolysis of acetylcholine.

Acetylcholinesterase

A hydrolase in the membrane of postsynaptic cells which metabolises acetylcholine into choline and acetic acid in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impulse.
Location CNS, red cells, motor endplates

acetylcholinesterase

Neurophysiology A hydrolase that metabolizes acetylcholine to acetyl and choline in the synaptic cleft, restoring it to a ground state, in preparation for the next nerve impule; acetylcholinesterase is found in the CNS, RBCs, motor endplates

a·ce·tyl·cho·lin·es·ter·ase

(AChE) (as'ĕ-til-kō'lin-es'tĕr-ās)
One of a family of enzymes capable of catalyzing the hydrolysis of acetylcholine.

acetylcholinesterase

An ENZYME that rapidly inactivates ACETYLCHOLINE by breaking it down to acetic acid and choline. Also known as cholinesterase.

acetylcholinesterase

the enzyme present in the synaptic cleft that destroys acetylcholine (see END PLATE).

Acetylcholinesterase

An enzyme that breaks down acetylcholine.
Mentioned in: Insecticide Poisoning

acetylcholinesterase 

An enzyme that degrades and inactivates acetylcholine. This compound is mainly found in neurons and at neuromuscular junctions. Drugs that inhibit this enzyme (e.g. diisopropyl fluorophosphate, physostigmine, edrophonium, echothiophate, DFP) can be used in the diagnosis and possible treatment of myasthenia gravis as well as certain forms of esotropia and glaucoma. Syn. specific cholinesterase. See anticholinesterase drugs.

a·ce·tyl·cho·lin·es·ter·ase

(as'ĕ-til-kō'lin-es'tĕr-ās) [MIM*100740]
Cholinesterase that hydrolyzes acetylcholine to acetate and choline within the central nervous system and at peripheral neuroeffector junctions (e.g., motor endplates and autonomic ganglia).
References in periodicals archive ?
Chauhan, "Acetylcholinesterase inhibition-based biosensors for pesticide determination: a review," Analytical Biochemistry, vol.
Application to acetylcholinesterase inhibitor galantamine and its determination in pharmaceuticals and human urine," Talanta, vol.
Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo.
Quinn, "Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states," Chemical Reviews, vol.
Mohamed, "The role of extracellular [Ca.sup.2+] on the inhibitory effects of acetylcholinesterase activity in Haruan, Channa Striatus block, brain tissue by heavy metals," Malaysian Applied Biology, vol.
GulcA,in, Synthesis and investigation of the conversion reactions of pyrimidine-thiones with nucleophilic reagent and evaluation of their acetylcholinesterase, carbonic anhydrase inhibition and antioxidant activities, J.
A natural inhibitor of the acetylcholinesterase enzyme has been discovered in a novel extract from sage.
Levels of total acetylcholinesterase in Drosophila melanogaster in relation to insecticide resistance.
The plants that yielded the best results were then subjected to acetylcholinesterase inhibition tests.
In conclusion, a series of jatrorrhizine derivatives with substituted amino groups linked at the 3-position were designed, synthesized, and biologically evaluated as inhibitors of acetylcholinesterase. All these jatrorrhizine derivatives were proved to be potent inhibitors of acetylcholinesterase (AChE) with submicromolar [IC.sub.50] values, but less sensitive to butyrylcholinesterase (BuChE), which suggests that these jatrorrhizine derivatives are selective for AChE/BuChE.
Treatment of MG is with acetylcholinesterase inhibitors and immunosuppression.
Pohanka, "Acetylcholinesterase inhibitors: a patent review (2008 present)," Expert Opinion on Therapeutic Patents, vol.

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