Effects of dietary factors and the NAT2 acetylator
status on gastric cancer in Koreans.
Polymorphisms in this gene are responsible for the N-acetylation process in which humans are segregated into rapid, intermediate or slow acetylator
There is need for vigilance regarding neurological effects of isoniazid in seemingly low-risk individuals in whom development of symptoms should raise the suspicion about slow acetylator
Determination of human NAT2 acetylator
genotype by restriction fragment-length polymorphism and allele-specific amplification.
Influence of acetylator
phenotype on the haematological and biochemical effects associated with dapsone in leprosy patients.
The most important risk factors in individuals receiving TB treatment are: age > 35 years; being a child; perhaps female gender; hepatitis B surface antigen (HBsAg) positivity, particularly if eAg-positive; use of alcohol; slow acetylator
status; extensive TB disease; increase in baseline alanine transaminase (ALT); malnutrition; hepatitis C virus (HCV) co-infection; and HIV co-infection.
Novel function of calreticulin: characterization of calreticulin as a transacetylase-mediating protein acetylator
independent of acetyl CoA using polyphenolic acetates.
5) Dietary intake (c) Vitamin B1 ([micro]g/day/kcal) 645 -- Vitamin B2 ([micro]g/day/kcal) 645 -- Vitamin B3 ([micro]g/day/kcal) 645 -- Vitamin B6 ([micro]g/day/kcal) 645 -- Vitamin B12 ([micro]g/day/kcal) 645 -- Folate ([micro]g/day/kcal) 645 -- Protein ([micro]g/day/kcal) 645 -- Alcohol ([micro]g/day/kcal) 645 -- Fruit (g/day/kcal) 639 -- Vegetable (g/day/kcal) 640 -- Fruit and vegetable 639 -- (g/day/kcal) Toenail trace elements ([micro]g/g) (d) Aluminum 658 -- Arsenic 659 -- Cadmium 659 -- Chromium 658 -- Copper 659 -- Iron 657 -- Lead 659 -- Manganese 659 -- Nickel 659 -- Selenium 659 -- Vanadium 651 -- Zinc 659 -- NAT2 phenotype Rapid/intermediate acetylator
Patients with a slow acetylator
status, renal or hepatic insufficiencies, the elderly and those with an underlying malignancy, autoimmune disease or HIV/AIDS are the ones most often affected.
4) showed that the metabolism of the drug was high in the body that may be due to fast acetylator
The N-Acetyltransferase 2 (NAT2) polymorphism is one of the most common inherited variations in the biotransformation of drugs and chemicals and large number of studies has been done to determine the distribution of NAT2 acetylator
phenotypes among populations of different geographic origins.
Several risk factors for hepatotoxicity have been suggested (8) such as advanced age, sex, poor nutritional status, liver disease, inappropriate use of drugs, infection with hepatitis B virus (HBV), hepatitis C virus and human immunodeficiency virus (HIV), acetylator
status, and high alcohol intake.