Acetylation and deacetylation on different positions of the N-terminal tail of core histones by histone acetylases
(HATs) and histone deacetylases (HDACs) change the nucleosomal conformation of cells .
Activity of many histone acetylase
enzymes would result in deacetylation of histone H3 in the tumor suppressor gene .
Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase
complex and induces vascular leakage in endothelial cells.
This increase in acetylation may result either from a decrease in the activity of the enzyme that removes acetyl groups (i.e., histone deacetylase) or an increase in the activity of the enzyme that adds acetyl groups (i.e., histone acetylase
BRCA2 interacts with the histone acetylase
P/CAF (Scully and Livingston, 2000) BRCA2-associated factor BRAF35 and DSS1.
First, a DNA fragment spanning 1212 bp, which contained the whole coding region of the NAT2 gene, was amplified from genomic DNA from study samples by use of primers specifically designed to amplify the NAT2 gene, avoiding amplification of the highly homologous genes N-acetyltransferase 1 (arylamine N-acetyltransferase) (NATI) and arylamide acetylase
pseudogene (AACP; also known as NATP) (7).
That year, Allis' group identified the first histone acetylase
, an enzyme that places acetyl groups on histone tails.
Kuwata et al., "Distinct but overlapping roles of histone acetylase
PCAF and of the closely related PCAF-B/GCN5 in mouse embryogenesis," Proceedings of the National Academy of Sciences of the United States of America, vol.
In a mouse model of cardiac hypertrophy, curcumin can suppress the acetylase
p300/CBP, consequently decreasing both inflammatory and fibrotic responses [170, 171].
Differential requirement of histone acetylase
and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.
Effects of gonadal steroids on activities of monoaminooxidase and choline acetylase
in the brain.
High-level gentamicin resistance is associated with a bifunctional enzyme possesing acetylase
(6') and phosphotransferase (2') activities (Table I) (33), conferring resistance to all aminoglycosides except streptomycin.