acetyl-CoA ligase

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a·ce·tyl-CoA li·gase

(as'ĕ-til lī'gās)
A ligase that catalyzes the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate.
Synonym(s): acetate thiokinase, acetate-CoA ligase, acetyl-activating enzyme, acetyl-CoA synthetase.
References in periodicals archive ?
We have also found that a key metabolic enzyme, acetyl-CoA synthetase, has a conserved lysine residue that in other bacteria is known to be acetylated.
Yamamoto, "Acetyl-CoA Synthetase 2, a Mitochondrial Matrix Enzyme Involved in the Oxidation of Acetate," The Journal of Biological Chemistry, vol.
Acyl-CoA Synthetase and Acetyl-CoA Synthetase are enzymes present in the fatty acid metabolism, preserved in D.
Acetate freely diffuses to most organs where it is utilized by Acetyl-CoA Synthetase to generate Acetyl-CoA.
The pyruvate that is generated by glycolysis is oxidized by pyruvate ferredoxin oxidoreductase (POR) [7] to yield C[O.sub.2] and acetyl-CoA, and energy is conserved in the form of ATP by an ADP-dependent acetyl-CoA synthetase that generates acetate [8].
found that both PPAR[alpha] and its target gene glucose transporter type 4 (Glut4) and acetyl-coA synthetase (Acs1) were significantly downregulated in the activity phase in mouse heart when cardiac tissue overexpressed PPAR[gamma] coactivator 1a (PGC-1[alpha]).
The acetate formed can be converted back to acetyl-CoA by acetyl-CoA synthetase (acs) and by reversing the pta-ackA pathway.
Of the three enzymatic pathways involved in the production of acetyl-CoA, the most prevalent in eukaryotes is the AMP-forming acetyl-CoA synthetase (AMP-ACS).
By the late 1980s, most scientists thought acetyl-CoA came from the enzyme acetyl-CoA synthetase (ACS).
It could be suggested that chromosome 3 carries the gene producing acetyl-CoA synthetase (ACS; EC 6.2.1.1), which is the enzyme necessary for the conversion of acetate to acetyl-CoA (Chakir et al.
This could point to a less efficient acetyl-CoA synthetase (EC 6.2.1.1) in adults when compared with larvae.
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proceedings of the National Academy of Sciences of the United States of America 103:10230-10235, 2006.