acetyl-CoA ligase

(redirected from acetyl-CoA synthetase)
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a·ce·tyl-CoA li·gase

(as'ĕ-til lī'gās)
A ligase that catalyzes the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate.
Synonym(s): acetate thiokinase, acetate-CoA ligase, acetyl-activating enzyme, acetyl-CoA synthetase.
References in periodicals archive ?
Of the three enzymatic pathways involved in the production of acetyl-CoA, the most prevalent in eukaryotes is the AMP-forming acetyl-CoA synthetase (AMP-ACS).
By the late 1980s, most scientists thought acetyl-CoA came from the enzyme acetyl-CoA synthetase (ACS).
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.