acetyl-CoA


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Related to acetyl-CoA: NADH, pyruvate, Acetyl-CoA carboxylase

a·ce·tyl-CoA

(a-sĕ'til),
Condensation product of coenzyme A and acetic acid, symbolized as CoAS~COCH3 or as AcCoa; an intermediate in the transfer of two-carbon fragments, notably in the tricarboxylic acid cycle and in fatty acid synthesis.

acetyl-CoA

(ə-sēt′l-kō′ā′, ăs′ĭ-tl-)

Acetyl-CoA

A coenzyme derivative in the metabolism of glucose and fatty acids that contributes substrates to the Krebs cycle. Acetyl CoA provides the acetyl for multiple biochemical reactions and plays a key role in intermediary metabolism—synthesis, catabolism, or use of nutrients for energy production and growth.

acetyl-CoA

Acetylcoenzyme A Metabolism A coenzyme derivative in the metabolism of glucose and fatty acids that contributes substrates to the Krebs cycle; acetyl CoA provides the acetyl unit for multiple biochemical reactions and plays a central role in intermediary metabolism–synthesis, catabolism, or use of nutrients for energy production and growth. See Citric acid cycle.

a·ce·tyl-CoA

(as'ĕ-til)
Condensation product of coenzyme A and acetic acid, symbolized as CoAS∼COCH3; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis.
References in periodicals archive ?
The acetyl-CoA produced is used directly in muscle as an energy substrate through the citric acid cycle, whilst in the liver it is degraded for the production of ketone bodies as an energy source in tissues such as brain (15).
Pyruvate dehydrogenase catalyzes the conversion of pyruvate to acetyl-CoA, the entry product for oxidative phosphorylation (Fig.
In anaerobic autotrophic bacteria, carbon fixation is accomplished by pathways that share the reductive synthesis of the common intermediate, acetyl-CoA, generated from 2[CO.sub.2] and 8[H] (Fuchs, 1989).
In the subsequent citric acid cycle, the acetyl-CoA is linked to a compound called oxaloacetate to form citric acid.
A high flux of carbon through acetyl-CoA, which is particularly enhanced in seeds of oil-accumulating plants such as Arabidopsis and Brassica, could result in a higher rate of PHB synthesis than in alfalfa leaves.
By the late 1980s, most scientists thought acetyl-CoA came from the enzyme acetyl-CoA synthetase (ACS).
Cole and Khalil made their new compound by connecting the molecule tryptamine, which is very similar to serotonin, to a variant of acetyl-CoA. The enzyme AANAT should readily take up this molecule, they reasoned, because it looks so much like the serotonin-acetyl-CoA combination.
All results suggest that in adults flies the metabolic fluxes from ethanol and acetic acid are mainly controlled by the same metabolic step, i.e., the transformation of acetate into acetyl-CoA.
We have also found that a key metabolic enzyme, acetyl-CoA synthetase, has a conserved lysine residue that in other bacteria is known to be acetylated.
The FAS, acetyl-CoA carboxylase a (ACC[alpha]), hormone sensitive lipase (HSL), and PEMT mRNA were expressed at a reduced rate (p<0.05) with choline supplementation.
The study combines the apoptosis signal-regulating kinase 1 inhibitor selonsertib with either the acetyl-CoA carboxylase inhibitor GS-0976 or the selective, non-steroidal Farnesoid X receptor agonist GS-9674.

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