The pharmacokinetics of diminazene aceturate
after intramuscular administration in healthy dogs.
Then, the AgNPs were conjugated with diminazene aceturate
, a drug used to treat animal trypanosomiasis .
Zhu et al., "Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate
ameliorates endotoxin-induced uveitis in mice," Investigative Ophthalmology & Visual Science, vol.
To observe the efficacy of the various drugs, Thirty Two positive cases were selected and divided into four groups, Group A was treated with Suramin, Group B with Isometamidium chloride, group C was treated with the Diminazine di aceturate
and group D was kept as control.
Watson, "A validated and stability indicating HPLC method for analysis of diminazene aceturate
and antipyrine combination in a ready injectable solution," Drug Research, vol.
(DIZE-ACE2 activator) induced beneficial cardiovascular effects through the attenuation of cerebral infarction (23), prevention of pulmonary hypertension (24), enhancement of cardiac function (25), and modulation of the autonomic nervous system (24).
The donor animal was later treated with 3.5 mg/ kg of 7% diminazene aceturate
through a deep intramuscular (i.m.) injection.
The final efficacy of oxytetracycline, imidocarb dipropionat and diaminazin aceturate
was 100,87.5 and 62.5%, respectively in small ruminants making oxytetracycline the most effective drug.
(DIZE), an activator of endogenous ACE2, is widely used as a trypanolytic agent in livestock that can activate the protective axis of RAS and counter-regulates the deleterious effects of Ang II .
Stephen, "Changes in haematological indices and protein concentrations in Trypanosoma brucei infected rats treated with homidium chloride and diminazene aceturate
," EXCLI Journal, vol.
Efficacy of imidocarb dipropionate along with oxytetracycline, imidocarb dipropionate alone, diminazene aceturate
along with oxytetracycline and diminazene aceturate
alone was 100,80, 80 and 70 percent in sheep whereas in goats 100, 80, 90 and 70 percent against babesia respectively, making imidocarb dipropionate along with oxytetracycline the most effective combination in both sheep and goats.