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any of a class of compounds that exert hypoglycemic activity by stimulating the islet tissue to secrete insulin; used to control hyperglycemia in patients with type 2 diabetes mellitus who cannot be treated solely by diet and exercise. The class includes the oral hypoglycemic agentsacetohexamide, chlorpropamide, glipizide, tolazamide, and tolbutamide.
acetohexamide/ac·e·to·hex·a·mide/ (as″ĕ-to-hek´sah-mīd) an oral hypoglycemic used in the treatment of type 2 diabetes mellitus.
a sulfonylurea oral antidiabetic.
indication It may be prescribed in the treatment of type 2 diabetes mellitus.
contraindications Its use is prohibited as sole therapy in type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney dysfunction, or known hypersensitivity to this drug or to other sulfonylureas.
adverse effects Among the most serious adverse reactions are blood dyscrasias, hypoglycemia, and allergic reactions. GI disturbances are common.
AcetohexamideA first-generation oral sulfonylurea used to reduce glucose in type 2 diabetics whose diabetes can’t be controlled by diet.
Mechanism of action Triggers release of insulin from the pancreas.
Pharmacokinetics Metabolised in liver to an active analogue; excreted via kidneys.
Adverse effects Hypoglycaemic reactions—e.g., coma, nausea, vomiting, dizziness, cholestatic jaundice, agranulocytosis, aplastic and haemolytic anaemia, hypersensitivity, skin reactions including photosensitivity, rash and itching.
Precautions Hypertension, liver and kidney disease, allergies
a first generation sulfonylurea derivative, used as an oral hypoglycemic agent in the treatment of diabetes mellitus.