Acetoacetyl-CoA thiolase | definition of acetoacetyl-CoA thiolase by Medical dictionary
acetyl-CoA acetyltransferase (redirected from acetoacetyl-CoA thiolase)
an acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis.
thiolase An obsolete generic term for any enzyme (e.g., acetyl CoA acetyltransferase [EC 184.108.40.206]) which catalyses a reaction between a compound, R–R’, and a thiol, R’–SH, forming R–S–R’ and R'–H.
a·ce·tyl-CoA a·ce·tyl·trans·fer·ase (as'ĕ-til as'e-til-trans'fĕr-ās)
References in periodicals archive
(35) The MVA pathway begins with the synthesis of acetoacetyl-CoA, which was first reported to be biosynthesized via a thioester-dependent Claisen condensation reaction between two molecules of acetyl-CoA, and is catalyzed by acetoacetyl-CoA thiolase
Activation of liver carnitine palmitoyltransferase-1 and mitochondrial acetoacetyl-CoA thiolase
is associated with elevated ketone body levels in the elasmobranch Squalus acanthias.
The second genetic disorder included in this study is an organic acid disorder called Mitochondrial acetoacetyl-CoA thiolase
(T2), commonly known as Beta-ketothiolase deficiency.
Activities of 3-hydroxybutyrate dehydrogenase, 3-oxoacid CoA-transferase and acetoacetyl-CoA thiolase
in relation to ketone-body utilisation in muscles from vertebrates and invertebrates.