Acetoacetyl-CoA | definition of acetoacetyl-CoA by Medical dictionary
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Intermediate in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA and in the degradation of ketogenic amino acids; major role is condensation with acetyl-CoA to form β-hydroxy-β-methylglutaryl-CoA.
Intermediate stage in the oxidation of fatty acids and in the formation of ketone bodies; also formed from two molecules of acetyl-CoA; major role is condensation with acetyl-CoA to form the important β-hydroxy-β-methylglutaryl-CoA.
Synonym(s): acetyl-coenzyme A
, active acetate
References in periodicals archive
at 340 nm using 50 [micro]M acetoacetyl-CoA
Acetyl-Coenzyme A acetyltransferase 2 (ACAT) transforms acetyl-CoA into acetoacetyl-CoA and can increases the rate of ketogenesis.
Purification, kinetic mechanism and regulation of different forms of mitochondrial acetoacetyl-CoA thiolases from ox liver.
5,512,669 claims gene(s) encoding acetoacetyl-CoA
reductase, an essential catalyst in the formation of the hydroxyacid intermediates.
Increased lipolysis results in the overproduction of acetoacetyl-CoA
, which then acts as the substrate for hepatic formation of ketone bodies.