Two substrates aniline and acetanilide
were used to see the effects of mercuric chloride on hydroxylation.
Brodie and Axelrod suggested that acetanilide
be replaced in Bromo Seltzer by acetaminophen.
Using the same mouse strains, ongoing studies in our laboratory have shown that PAP oxidized metabolites at the aniline moiety (66) and oxidized acetanilide
metabolites (67) were present in the animals' urine after intraperitoneal administration of [sup.
The dinitrogen gas from the combusted sample was then passed through a VG Isotech Iomass Spectrometer (model Sira Series If, Cheshire, UK) that was calibrated with acetanilide
standards and which quantified molecular mass peaks of 28, 29, and 30.
Zimdahl RL, Clark SK (1982) Degradation of three acetanilide
herbicides in soil.
Pesticides: Alachlor, Metolachlor, and Acetochlor.
Of 62 cases reviewed at the Mayo Clinic , all were associated with just four drugs, taken alone or in combination with other drugs: Bromo-Seltzer, acetanilide
, sulfonamide, and phenacetin.
Samples were analyzed in an elemental analyzer (Model 2400, Perkin-Elmer, Norwalk, Connecticut) using acetanilide
as a standard.
Samples were combusted in a Control Equipment Corporation (Perkin Elmer) 240 XA elemental analyzer with an automatic sampler in an air-tight box to keep the samples dry, and acetanilide
was used as a standard.
Calibration was performed with acetanilide
for CHN test and benzoic acid for oxygen test.
Elemental analysis was performed on a Flash EA1112 CHN-O-Rapid elemental analyzer using acetanilide