acetanilide


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ac·et·an·i·lide

(ăs′ĭt-ăn′l-īd′) or ac·et·an·i·lid (-ăn′l-ĭd)
n.
A white crystalline compound used to relieve pain and reduce fever.

acetanilid

, acetanilide (as″ĕ-tan′ĭl-ĭd, -īd″) (as″ĕ-tan′ĭl′īd″) [L. acetum, vinegar + anilide]
A white powder or crystalline substance obtained by interaction of glacial acetic acid and aniline.

Action/Uses

Acetanilid has analgesic, antipyretic, and anti-inflammatory effects. Acute or chronic poisoning may develop as a result of prolonged administration or drug idiosyncrasy. Because of its toxicity, it is rarely used.

References in periodicals archive ?
The heaviest [delta][sup.13]C value was determined for NaHC[O.sub.3] (-7.639[per thousand]) and the lightest for acetanilide (-34.318[per thousand]).
4-Hydroxyl acetanilide (3 mmol) was added to bromoalkanes (3 mmol) in the presence of [K.sub.2]C[O.sub.3] (3 mmol) in dry acetone (20 mL).
The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-amino-phenol, free and total conjugated, in biological fluids and tissues.
1998 Nonlinear enthalpy-entropy compensation for the solubility of drugs in solvent mixtures: paracetamol, acetanilide and nalidixic acid in dioxane-water.
Acetanilide at the time was already a widely-sold pain reliever, so he decided to add it.
The 1906 Pure Food and Drugs Act required some ingredients like alcohol, opium, chloral hydrate, and acetanilide to be listed on the label or package.
Adams exposed how some headache powders, for instance, often sold by door-to-door salesmen, actually contained high levels of acetanilide, a toxic and addictive painkiller that caused heart attacks and kidney disease.
In particular, the contribution of CYP1A and NAT2 enzymes to the metabolism of aniline-derived xenobiotics such as acetanilide and phenacetin is well known (63).
Nine compounds were studied: 4-hydroxybenzaldehyde, salicylaldehyde, acetanilide, 4-hydroxycoumarin, 7-hydroxycoumarin, indole-3, carboxaldehyde, salicylic acid, cinnamic acid and 2-hydroxy cinnamic acid.
Few other industrial chemicals (mainly nitrobenzene, acetanilide) and some pesticides (e.g., Fenuron) also result in the elimination of p-aminophenol.
The instrument was calibrated with an acetanilide standard.