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A fast-acting vitamin K-antagonist anticoagulant. In patients with proximal vein thrombosis, it can be co-administered with full-dose heparin.


A fast-acting vitamin K-antagonist anticoagulant

acenocoumarol, acenocoumarin

a warfarin derivative used as an anticoagulant. Called also nicoumalone.
References in periodicals archive ?
The antithrombotic therapy included warfarin and acenocoumarol within control groups, (19) and patients with modified therapy received therapy bridge (nadroparin calcium), (13) decreased dose of antithrombotic agent, or therapy suspension.
A case study of acenocoumarol sensitivity and genotype-phenotype discordancy explained by combinations of polymorphisms in VKORC1 and CYP2C9.
This was demonstrated in a cohort of 112 Dutch patients treated with acenocoumarol who received an NSAID (diclofenac, naproxen, or ibuprofen).
11) An open-label, randomized noninferiority study (EINSTEIN) compared rivaroxaban (15 mg twice daily for 3 weeks followed by 20 mg daily for 3, 6, or 12 months) to the low-molecular-weight heparin enoxaparin (1 mg/kg body weight, dosed twice daily) followed by either warfarin or acenocoumarol (to achieve an INR of 2-3) for patients with acute, symptomatic DVT.
Judes mechanical valve after taking excess of acenocoumarol for 4 days, (total dose 24mg) presented with two day history of sudden onset rapidly progressive weakness in right lower limb followed by left lower limb in a day with urinary retention and constipation.
5-5 mg twice a day, and triflusal 600 mg plus acenocoumarol to reach an INR target of 1.
His fever subsided, and he was discharged a few days later while continuing to receive acenocoumarol, an oral coumarin anticoagulant.
5 mg/wk and 2,293 to oral adjusted-dose vitamin K antagonists (warfarin or acenocoumarol, target international normalized ratio of 2.
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.