ACE

angiotensin

 (ACE) [an″je-o-ten´sin]

a vasoconstrictive substance formed in the blood when renin is released from the juxtaglomerular apparatus in the kidney. The enzymatic action of renin acts on angiotensinogen to form the decapeptide angiotensin I, which is relatively inactive. It in turn is acted upon by peptidases (converting enzymes), chiefly in the lungs, to form the octapeptide angiotensin II, a powerful vasopressor and a stimulator of aldosterone secretion by the adrenal cortex. By its vasopressor action, it raises blood pressure and diminishes fluid loss in the kidney by restricting blood flow. Angiotensin II is hydrolyzed in various tissues to form heptapeptide angiotensin III, which has less vasopressor activity but more effect on the adrenal cortex.

angiotensin-converting enzyme (ACE) an enzyme of the hydrolase class that catalyzes cleavage of a dipeptide from the C-terminal end of angiotensin I to form activated angiotensin II; called also peptidyl-dipeptidase A.

angiotensin-converting enzyme inhibitors competitive inhibitors of angiotensin-converting enzyme, which converts angiotensin I to angiotensin II and inactivates bradykinin. ACE inhibitors, such as captopril, are antagonists of the renin-angiotensin-aldosterone system and potentiators of the kinin system and are used for treatment of hypertension, usually in conjunction with a diuretic. They are also used as vasodilators in the treatment of congestive heart failure.

ACE

Abbreviation for angiotensin-converting enzyme.

ACE

(1) Abciximab & Carbostent Evaluation in Acute Myocardial Infarction. A trial comparing outcomes of carbon-coated stenting of an infarct-related artery with and without abciximab.
Primary endpoint 30-day MACE (major acute coronary events)
Conclusion Abciximab + IRA stenting may be a viable reperfusion strategy in patients with acute myocardial infarction undergoing primary percutaneous revascularization.
(2) ASA & Carotid Endarterectomy. A trial comparing high- and low-dose aspirin to reduce the risk of stroke in patients undergoing carotid endarterectomy.
Primary endpoints 30-day MACE (major acute coronary events), stroke
Conclusion Low-dose (80, 325 mg) ASA patients did better

ACE

Angiotensin-converting enzyme, see there. Cf ACE inhibitors, also

1. Acute Care for Elderly.

2. Adriamycin, cyclophosphamide, etoposide.

3. Alcohol, chloroform, ether–obsolete anesthetic cocktail.

4. American College of Epidemiology.

ACE

Abbreviation for angiotensin-converting enzyme.

ACE

See ANGIOTENSIN-CONVERTING ENZYME.