acedapsone

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Systematic reviews of historical evidence of the effectiveness of dapsone, acedapsone, rifampicin and combinations of rifampicin, minocycline and ofloxacin had shown their effectiveness.

19th International Leprosy Congress: the Plenary Sessions

Limited duration acedapsone prophylaxis in leprosy.

Review of chemoprophylaxis in leprosy contacts

This is in line with the WHO recommendations, (3,4) that family members of leprosy patients should be given 1-4 mg dapsone per kilogram (kg/body weight per week) as well as one time intramuscularly injection of acedapsone per 10 weeks interval as prophylactic treatment to protect household contacts.

Medical rehabilitation of leprosy patients discharged home in Abia and Ebonyi States of Nigeria

Evidence that bacterial persistence might be a problem in the treatment of lepromatous leprosy, also, came from a study of the Karimui of Papua New Guinea in which five of 28 lepromatous patients were found to have solid-staining bacilli (indicative of live bacilli) in their skin smears despite regular treatment with acedapsone for 3-5 years and expected blood sulphone levels.

Experience with acedapsone (DADDS) in the therapeutic trial in New Guinea and the chemoprophylactic trial in Micronesia.

The chemotherapy of leprosy: an interpretive history

One systematic review and metaanalysis published in 2000 (a review that pooled two duplicated studies) found that prolonged administration of dapsone and acedapsone could prevent leprosy development in contacts by 40.

Two studies evaluating an acedapsone dose every 10 weeks for 7 months were included (43, 44).

44) assessed the effectiveness of acedapsone with placebo in contacts of patients with multibacillary leprosy.

Meta-analysis of these two studies significantly favored acedapsone to placebo (2 RCT, 1 259 participants, RR 0.

Acedapsone (43, 44) and rifampicin (38, 39) were more effective than placebo and also presented a significant reduction (between 67% and 57%, respectively) in the incidence of leprosy in patients' contacts.

The results confirm the findings of a previous meta-analysis, where the authors found that prolonged administration of dapsone and acedapsone (20, 21) could prevent the appearance of leprosy among contacts by 40% to 60% compared with placebo (10).

Quimioprofilaxis en contactos de pacientes con lepra: revision sistematica y metanalisis

A meta analysis showed that chemoprophylaxis with oral dapsone or intramuscular acedapsone gave around 60% protection against leprosy.

Report of the workshop on the use of chemoprophylaxis in the control of leprosy held in Amsterdam, the Netherlands on 14 December 2006

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