accumulation

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accumulation

A build-up, assembly; the process of accumulating, collecting together.

Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.

Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.

References in periodicals archive ?

Of the 32 analyzed thunderstorms, 14 had traces of hail or accumulations under 3 cm (trace or small; see Fig.

CHAT: The Colorado Hail Accumulation from Thunderstorms Project: The CHAT project aims to collect hail accumulation reports and study the behavior of hail-producing thunderstorms with dual-polarization weather radars and a lightning mapping array

This behavior is common in some leafy vegetables (especially those with short growth cycles), which initially present a slow phase of accumulation of dry matter, intensifying at the end of the cycle.

Growth and accumulation of nutrients in organic jambu

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The total accumulations in the plant were 0.305, 0.358, 0.410, 0.515, 0.725 and 1.153 g [plant.sup.-1], respectively, for the cassava wastewater doses of 0, 8.5, 17, 34, 68 and 136 [m.sup.3] [ha.sup.-1], representing an increment of 277% of the highest dose (136 [m.sup.3] [ha.sup.-1]) in relation to the lowest one (0 [m.sup.3] [ha.sup.-1]), with extractions of 15.3, 17.9, 20.5, 25.7, 36.2 and 57.6 kg [ha.sup.-1], respectively.

Accumulation of macronutrients in different parts of sunflower fertilized with cassava wastewater/Acumulo de macronutrientes em distintas partes de girassol adubado com manipueira

Accumulation of metals in muscle was observed to follow the order of Cu > Zn > Mn > Pb >Cd.

Heavy Metal Concentration in Sardinella longiceps (Valeciennes, 1847) from Balochistan Coast

However, only nineteen states require that municipalities exercise a duty of reasonable care for natural accumulations on streets and sidewalks, while the remaining thirty-one states grant municipalities some form of immunity for natural accumulations.

Papadopoulos v. Target: finally melting away the century-old natural accumulation standard in Massachusetts

The main difference between conventional and unconventional accumulations is the ease with which oil and gas flows through the formation.

Shale dilemma for oil producers

Curveexpet software (version 1.3) was used in this study to draw the accumulation of Hg and As in plant tissues relative to time.

Ability of four species aquatic plants for heavy metals (as and hg) removal in arid and semi-arid conditions (Case Study: Dezful, Iran)

We no longer need to gloss over the critical accumulation process by dramatizing the glorious thoughts of the distribution of the accumulations.

A perfect pair: disability insurance and retirement planning: it's unfashionable to be a worrywart these days, but an unexpected disability can ruin even the best-laid retirement plans. Whether your client is young or old, it makes sense to discuss adding DI to the mix when plotting long-term financial strategies

Basically, it is represented by the diffuse localized intra-tissue lymphocytes and its accumulation and formed nodes, and also by insignificant accumulation of these nodes which could rarely happen.

Age morphology of immune structures of rabbit's jejunum in the period of the early postnatal ontogenesis

One basis for the natural accumulation rule is that natural accumulation of ice and snow is open and obvious.

The politics of shoveling: No shovel? No salt? No liability, in some cases

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