accumulation

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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in periodicals archive ?
This behavior is common in some leafy vegetables (especially those with short growth cycles), which initially present a slow phase of accumulation of dry matter, intensifying at the end of the cycle.
Insurers that are able to consistently capture structured cyber exposure data, develop scenarios and analytical capabilities, and are able to efficiently manage their cyber accumulations risk, will be in a better competitive position to profitably expand their cyber insurance capacity over time.
The total accumulations in the plant were 0.305, 0.358, 0.410, 0.515, 0.725 and 1.153 g [plant.sup.-1], respectively, for the cassava wastewater doses of 0, 8.5, 17, 34, 68 and 136 [m.sup.3] [ha.sup.-1], representing an increment of 277% of the highest dose (136 [m.sup.3] [ha.sup.-1]) in relation to the lowest one (0 [m.sup.3] [ha.sup.-1]), with extractions of 15.3, 17.9, 20.5, 25.7, 36.2 and 57.6 kg [ha.sup.-1], respectively.
Accumulation of metals in muscle was observed to follow the order of Cu > Zn > Mn > Pb >Cd.
However, only nineteen states require that municipalities exercise a duty of reasonable care for natural accumulations on streets and sidewalks, while the remaining thirty-one states grant municipalities some form of immunity for natural accumulations.
The main difference between conventional and unconventional accumulations is the ease with which oil and gas flows through the formation.
Curveexpet software (version 1.3) was used in this study to draw the accumulation of Hg and As in plant tissues relative to time.
Basically, it is represented by the diffuse localized intra-tissue lymphocytes and its accumulation and formed nodes, and also by insignificant accumulation of these nodes which could rarely happen.
One basis for the natural accumulation rule is that natural accumulation of ice and snow is open and obvious.
Acacia Life (UNIFI Co) Flex-Account Ultra Death Benefit Sales; Accumulation Sales; Long-Term Values; Maximum Retirement Income; Living Benefits