accumulation


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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in periodicals archive ?
Several insurers are hesitant to expand their cyber insurance portfolios due to the rapidly shifting nature of cyberrisks, lack of historical loss data, uncertainty around risk accumulation processes and nascent cyber reinsurance/retrocession markets.
As to N accumulation in the sunflower stem, the maximum and minimum values estimated by the regression equations were 0.
As of today, Accumulation VUL with Vitality is available in 34 states and John Hancock will continue to roll it out across the country.
In Aleppo, all roads are passable except the road of Khanaser-al-Sfira- Salamiya which is hardly passable due to the accumulation of snow, and in Idleb all roads are open except the road of Idleb-Ariha, Ariha-Mahambel-Bsonqul and Jisr al-Shoughur-Lattakia-al-Ghab due to the accumulation of snow.
The values of Tb To and Tm of cotton were set as follows: from sowing to emergence Tb = 12 C To = where RAGBAi is the relative aboveground biomassaccumulation within growth stage i; AGBAi is themeasured accumulation of aboveground biomass-2 30 C and Tm = 45 C; from emergence to boll openingTb = 12 C To = 30 C and Tm = 35 C (Guan et al.
Day, has a 70 percent chance of snow, according to the weather service with a possible accumulation of 1 to 3 inches of new snow, and a high temperature of 33 degrees.
Another disorder with symptoms that occur during the ripening period has been called 'berry shrivel'; we recently proposed that it be called 'sugar accumulation disorder' (Krasnow et al.
One basis for the natural accumulation rule is that natural accumulation of ice and snow is open and obvious.
During the accumulation phase premium payments are applied toward the purchase of accumulation units.
Accumulation Values; Business Applications; Long Term Values
1) Some HIV-positive patients receiving HAART also develop "lipodystrophic" features, that is, loss of fat in some parts of the body (especially the face, arms, and legs) (2,3) as well as accumulation of fat in other parts of the body (such as the dorsocervical area, (4,5) trunk, and abdomen.