accumulation


Also found in: Dictionary, Thesaurus, Financial, Encyclopedia, Wikipedia.

accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in periodicals archive ?
WASA's spokesperson Imtiaz Ghori said, 'It was normal rain of 16 millimetres and WASA staff kept all the locations clear of water accumulation. Localities, where there was more water accumulation, are being cleared by WASA using machinery.'
The relationship between hail accumulation and time-averaged maximum VII leads to clustering into three main groups: i) storms with low VII of <50 kg [m.sup.-2] produced <3 cm of accumulated hail and had low accumulation rates of <0.4 cm [min.sup.-1]; ii) storms with moderate VII between 50 and 150 kg [m.sup.-2] produced moderate-to-deep hail accumulations and had moderate-to-fast (0.4-0.9 cm [min.sup.-1]) time-averaged accumulation rates, depending on the storm speed; and iii) storms with large VII of >150 kg [m.sup.-2] produced deep hail (>10 cm) and accumulation rates of 0.9-2.5 cm [min.sup.-1].
The amount of N, P, K, Ca and Mg accumulated during the jambu growth cycle showed similar trends to dry matter accumulation, ie, 18 DAT.
'The steepest slowdowns in capital accumulation are expected in China, where policy efforts to rein in credit growth continue, and the Philippines, where a surge in public investment is expected to fade,' it said.
* TEF Conveyor and TEF Accumulation Table handle round, square, and rectangular bottles made of plastic or glass that are up to 2500 cc in size
The accumulation of nutrients was determined through the multiplication of the concentration of the nutrient by the dry mass corresponding to each plant part.
Key words: Vetiver; Imperata; Pennisetum; Spiked heavy metal; Heavy metal accumulation.
Industrial and agricultural activities have been reported to be the leading potential source of the accumulation of pollutants in the aquatic environment including the sea (Tarra-Wahlberg et al., 2001; Akif et al., 2002).
The ZoneFlex Advanced maximizes carton control and boosts throughput in zero-pressure accumulation conveyor applications.
Mir1-CP accumulation is regulated by the jasmonic-acid (JA) pathway.