accessory molecules

ac·ces·so·ry mol·e·cules

surface receptors on immune cells, which participate in cell-cell interactions and modulate the immunologic outcome. For example, in T-cell recognition of B-cell presented-antigen, the primary interaction occurs through CD3-CD4 binding to MHC and antigen, but this interaction is amplified if concomitant accessory molecule binding also occurs, for example, CD28 to B7.

ac·ces·so·ry mol·e·cules

(ak-ses'ŏr-ē mol'ĕ-kyūlz)
Cell surface adhesion molecules on T cells that are involved in binding of one cell to another cell or in signal transduction.
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References in periodicals archive ?
To date, very little is known about how these subunits combine, what other proteins act as accessory molecules interacting with receptor subunits, or what impact the 'parts list' of each complex has on its pharmacological properties.
Among the accessory molecules involved in the activation of naive [CD4.sup.+] T lymphocytes, the up-regulation of CD40 is of particular interest in AS because the CD40 pathway is intimately involved in exaggerated inflammation (24).

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