1124 + 41 was activated in the mutant construct, and the normal intron 9 acceptor site
The resulting cations are best described as 1:1 adducts of a neutral ligand on a phosphadiazonium Lewis acceptor (1), and highlight the potential for electron-rich centres to behave as Lewis acids in spite of the presence of a lone pair of electrons at the acceptor site
Pentachlorophenol, a SULT acceptor site
inhibitor, prevented binding of 7-HC at all conditions.
The 5T variant is a poor splice acceptor site
and gives rise to skipping of exon 9 in a high percentage of CFTR mRNA transcripts (7-11).
Botulinum toxin type A is known to block neuromuscular transmission by binding to acceptor sites
on motor or sympathetic nerve terminals, entering the nerve terminals and inhibiting the release of acetylcholine.
We estimated H-bond interaction energies of the putative donor and acceptor sites
on the natural AR ligand, DHT, and selected nonsteroidal analogues using the PM3 method to compute the energies of interaction with a single water molecule at each site; PM3 fully optimized conformations of the water-bound species were computed for this purpose.