However, this variant affected splice acceptor site
directly, thus it might interrupt the recognition of spliceosomes and result in incorrect splicing.
The prediction of the consequence of XRCC7 -6721G>T mutation via HSF 3 tool showed that this SNP occurred in an acceptor splicing site and the transversion of allele G to allele T causes the increase of HSF score of the mutation and also increased slightly the upstream acceptor splicing site's HSF score, but not created new cryptic splice acceptor site
The DCMU causes a limitation to the acceptor site
of the electron transfer in PSII, preventing reoxidation of [Q.sub.A.sup.-] by intersystem electron transport (HSU, 1992; TOTH et al., 2005).
One acceptor site
A2 having score -0.22 has also been shown.
A cryptic donor splice site between c.1124 + 40 and c.1124 + 41 was activated in the mutant construct, and the normal intron 9 acceptor site
The resulting cations are best described as 1:1 adducts of a neutral ligand on a phosphadiazonium Lewis acceptor (1), and highlight the potential for electron-rich centres to behave as Lewis acids in spite of the presence of a lone pair of electrons at the acceptor site
. Phosphadiazonium cations with both bidentate- and tridentate-chelating ligands (2 and 3), as well as donor-rich adducts (4) where more than one monodentate ligand coordinates to the phosphadiazonium acceptor have also been prepared.
These compounds did not, however, provide a good candidate feature for D-ring H-bond interaction according to the "near-10 [Angstrom] polar interactions rule" (the thiol was computed to be a 7.5 [Angstrom] separation from the A-ring H-bond acceptor site
), which is consistent with lack of reported agonist properties.
Pentachlorophenol, a SULT acceptor site
inhibitor, prevented binding of 7-HC at all conditions.
The introns display boundary sequences at a 5[feet] donor site and a 3[feet] acceptor site
. The nucleotide sequence flanked by the donor and acceptor site
loop out and are removed enzymatically; the remaining exons are then linked together [ILLUSTRATION FOR FIGURE 3 OMITTED].
Ionic attachment will only be achieved if an |appropriate' acceptor site
exists on the particle surface.
The third was a adenine-to-cytosine transversion at position -2 of the splice acceptor site
in intron 19 (g.IV519-2A>C; see Fig.
In conclusion, it seems that a suboptimal 5' splice site (donor site) and 3' splice site (branch point, pY tract, and acceptor site
) play a major role in intron III retention of these genes.