accelerator hypothesis

accelerator hypothesis

A theory regarding the pathogenesis of type-1 diabetes which holds three processes responsible:
• Loss of pancreatic beta cells through apoptosis;
• Individual constitution;
• Insulin resistance and autoimmunity.
References in periodicals archive ?
These similarities between the two types, along with the presence of a hybrid form, argue for the "accelerator hypothesis," which views type 1 and type 2 diabetes as the same disorder of insulin resistance, set against different genetic backgrounds, Dr.