accelerated fractionation

accelerated fractionation

The delivery of radiation at a rate of accumulation that is up to 50% faster than that of standard fractionation, which substantially decreased duration of therapy and decreased potential for tumour repopulation between fractions.

accelerated fractionation

Radiation oncology The delivery of radiation at a rate of accumulation that is up to 50% faster than that of standard fractionation, which substancially ↓ duration of therapy, and ↓ potential for tumor repopulation between fractions. See Fractionation. Cf Hyperfractionation.
References in periodicals archive ?
A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003.
Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: Results of the EORTC 22851 randomized trial.
Conventional vs accelerated fractionation in head and neck cancer.
The long-term toxicity of high-dose radiation is often underappreciated, but it is clear that chronic fibrosis, edema, tissue necrosis, and dysphagia are not uncommon and that their incidence increases with more aggressive accelerated fractionation schemes and with long-term (>5 yr) follow-up.
Newer strategies of hyperfractionation and accelerated fractionation lead to 7% to 10% improvement in locoregional control compared to once-daily treatment schemes.
Thames et al (1983) reviewed the rationale behind the accelerated fractionation and discussed the result of some multiple-dose fraction in the form of accelerated and hyperfractionation.
Accelerated fractionation has shown an increase in early and late radiation damage, their interval has been between 2 to 4 hours.
Accelerated fractionation is a means of decreasing the overall duration of treatment in an effort to reduce the repopulation of tumor cells in rapidly proliferating cancers.
A variant of accelerated fractionation is the concomitant-boost technique.
This hybrid regimen incorporates features of both accelerated fractionation and hyperfractionation.
RTOG 90-03 was a large randomised trial comparing Standard Fractionation (SFX) against Hyper-Fractionation (HFX), Accelerated Fractionation with Split-course (AFX-S), and Accelerated Fractionation by Concomitant Boost (AFXCB) in the management of patients with advanced HNSCC.

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