acanthosis nigricans


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.

acanthosis

 [ak″an-tho´sis]
diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic.
acanthosis ni´gricans diffuse acanthosis with gray, brown, or black pigmentation, chiefly in the axillae and other body folds, occurring in an adult form, often associated with an internal carcinoma (called malignant acanthosis nigricans) and in a benign, nevoid form, more or less generalized. A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans. (See Atlas 2, Part E).

ac·an·tho·sis ni·'gri·cans

[MIM*100600]
an eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders (characterized by insulin resistance), or obesity; seen in Type 2 diabetes in adolescents; a benign hereditary type occurs in children.
See also: pseudoacanthosis nigricans.
[L. fr. niger, black]

acanthosis nigricans

(nī′grĭ-kănz′, nĭg′rĭ-)
n.
An eruption of velvety wartlike growths accompanied by hyperpigmentation in the skin of the axillae, neck, anogenital area, and groin, occurring in a benign form in children, but associated with internal malignancy or reticulosis in adults.

acanthosis nigricans

[nē′grikanz′]
a skin disease characterized by hyperpigmented, velvety thickening of the skin, common in the neck, axilla, and groin. There are benign and malignant forms; the latter is most often associated with cancers of the GI tract. See also acanthosis.
enlarge picture
Acanthosis nigricans

acanthosis nigricans

A condition characterised by dark, hyperkeratotic and papillomatous changes of the skin in body folds, including the axilla, groin, umbilicus, neck. It is associated with diabetes and internal malignancy, typically adenocarcinoma, especially of the GI tract and uterus. Treatment of the underlying condition usually results in resolution of the skin lesions.

Forms
• Malignant—associated with cancer (CA), e.g., gastric CA, but also rarely Hodgkin’s disease, or osteosarcoma.
• Inherited.
• Endocrine-related—Associated with pituitary tumours, polycystic ovary syndrome, insulin resistance, obesity.
• Idiopathic.
• Benign acanthosis nigricans (AN).
• AN associated with obesity.
• Syndromic AN.
• Malignant AN.
• Acral AN.
• Unilateral AN.
• Drug-induced AN.
• Mixed AN.

acanthosis nigricans

Dermatology A condition characterized by hyperkeratosis and papillomatosis Forms Malignant–associated with CA–eg, gastric CA, but also rarely Hodgkin's disease, or bone CA; inherited; endocrine–associated with pituitary tumors, polycystic ovary syndrome, insulin resistance, idiopathic

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz)
An eruption of velvet warty benign growths and hyperpigmentation occurring in the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders, or obesity; a benign type occurs in children.
[L. fr. niger, black]

acanthosis nigricans

Black or brown pigmented warty areas overlying patches of ACANTHOSIS. These occur in the armpits and other body folds and may sometimes be associated with ACROMEGALY, ADDISON'S DISEASE, POLYCYSTIC OVARY, intestinal CANCER or the INSULIN RESISTANCE SYNDROME.

Acanthosis nigricans

A dark brownish or blackish discoloration of the skin related to overweight and high levels of insulin in the blood. Acanthosis nigricans is most likely to develop in the groin or armpits, or around the back of the neck.
Mentioned in: Insulin Resistance

Miescher,

Alfred Guido, Swiss dermatologist, 1877-1961.
Miescher cheilitis - Synonym(s): Melkersson-Rosenthal syndrome
Miescher-Leder syndrome - reddish granulomatous plaques. Synonym(s): granuloma disciformis; necrobiosis maculosa
Miescher I syndrome - benign velvety warty growths. Synonym(s): acanthosis nigricans
Miescher II syndrome - inflammatory granulomas of the lips. Synonym(s): granulomatous cheilitis

acanthosis nigricans 

A rare skin disorder presenting numerous superficial, pigmented papillomatous growths on various parts of the body. Ocular manifestations are primarily papillomatous lesions of the lid margins, which may be so extensive as to cause punctal occlusion, as well as papillary conjunctivitis. Syn. keratosis nigricans.

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz) [MIM*100600]
Eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin.
[L. fr. niger, black]

acanthosis

an increased thickness of the stratum spinosum, due to either an increased number or hypertrophy of cells.

frictional acanthosis
see acanthosis nigricans (below).
acanthosis nigricans
a skin disease of dogs characterized by hyperpigmentation, lichenification, seborrhea, and alopecia commencing in the axillae and often spreading to involve flexural surfaces of all limbs, and the ventral body. Dachshunds are particularly predisposed to primary acanthosis, often developing the first changes at a young age. Sporadic cases are secondary to systemic disease, endocrinopathies, hypersensitivity reactions and friction in body folds.
References in periodicals archive ?
Schwartz, "Juvenile acanthosis nigricans," Journal of the American Academy of Dermatology, vol.
Hyperinsulinemia associated with acanthosis nigricans, finger pebbles, acrochordons, and the sign of Leser-Trelat.
Conclusion: Acanthosis nigrican, raised WHR and FBS are significant parameters for insulin resistance in cases of Poly Cystic Ovary Syndrome (PCOS).
The diagnosis of T1DM was made based on the classical history of DM, thin body built, absence of acanthosis nigricans with the presence of pancreatic auto-antibodies His presentation was similar to previously reported cases of children with HHS (8-10).
His cross-sectional study found that 47 of 150 acanthosis nigricans patients (31%) were insulin resistant; acanthosis nigricans grades of 3 or 4 were more predictive of the condition.
2) Altenburger et al (1) mentioned the detailed differential diagnoses of black esophagus, including melanosis, pseudomelanosis, coal dust deposition, corrosive ingestion, and acanthosis nigricans.
Conclusion: Skin tag, plantar hyperkeratosis, fungal infections, striae and acanthosis nigricans were found to be the most common skin diseases in obese patients in our study.
Recently, nurses have started looking for early signs of type 2 diabetes, such as acanthosis nigricans, which is dark, thick skin found in body folds and creases.
Two dermatological indications are multiple skin tags and acanthosis nigricans, a disorder in which velvety, dark markings appear on the skin, especially in the skin folds of the neck, groin, armpits and under the breasts.
Rare pre adolescence Thin patient Obese (85% of cases) Family history absent or of type 1 Family of history of T2DM (45 - DM 80% cases) High-risk ethnic group No features of insulin resistance Features of metabolic syndrome: (although can be overweight) (hypertension, hypercholesterolaemia, acanthosis nigricans, NAFLD, PCOS) Frequent ketosis and severe Mild DKA possible; 33% with acidosis ketonuria C-peptide low C-peptide higher or recovers Two or more +ve antibodies May have low positive anti-GAD (anti-GAD, anti-IA2, anti-ICA) as additional risk
The symptoms of androgen disorders should not be dismissed or ignored - androgen dominance is associated with estrogen proliferative cancers, (3) acanthosis nigricans, (4) increased cardiovascular disease, and abnormal lipid metabolism.
Students received a minimal medical history and clinical exam annually to record blood pressure, weight and height, sleep disturbance, severe back pain, and non-invasive screening for acanthosis nigricans (dark hyperpigmentation markings that occur at folds and creases of the skin) as a marker for Type II diabetes.