acanthosis nigricans


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acanthosis

 [ak″an-tho´sis]
diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic.
acanthosis ni´gricans diffuse acanthosis with gray, brown, or black pigmentation, chiefly in the axillae and other body folds, occurring in an adult form, often associated with an internal carcinoma (called malignant acanthosis nigricans) and in a benign, nevoid form, more or less generalized. A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans. (See Atlas 2, Part E).

ac·an·tho·sis ni·'gri·cans

[MIM*100600]
an eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders (characterized by insulin resistance), or obesity; seen in Type 2 diabetes in adolescents; a benign hereditary type occurs in children.
See also: pseudoacanthosis nigricans.
[L. fr. niger, black]

acanthosis nigricans

(nī′grĭ-kănz′, nĭg′rĭ-)
n.
An eruption of velvety wartlike growths accompanied by hyperpigmentation in the skin of the axillae, neck, anogenital area, and groin, occurring in a benign form in children, but associated with internal malignancy or reticulosis in adults.

acanthosis nigricans

A condition characterised by dark, hyperkeratotic and papillomatous changes of the skin in body folds, including the axilla, groin, umbilicus, neck. It is associated with diabetes and internal malignancy, typically adenocarcinoma, especially of the GI tract and uterus. Treatment of the underlying condition usually results in resolution of the skin lesions.

Forms
• Malignant—associated with cancer (CA), e.g., gastric CA, but also rarely Hodgkin’s disease, or osteosarcoma.
• Inherited.
• Endocrine-related—Associated with pituitary tumours, polycystic ovary syndrome, insulin resistance, obesity.
• Idiopathic.
• Benign acanthosis nigricans (AN).
• AN associated with obesity.
• Syndromic AN.
• Malignant AN.
• Acral AN.
• Unilateral AN.
• Drug-induced AN.
• Mixed AN.

acanthosis nigricans

Dermatology A condition characterized by hyperkeratosis and papillomatosis Forms Malignant–associated with CA–eg, gastric CA, but also rarely Hodgkin's disease, or bone CA; inherited; endocrine–associated with pituitary tumors, polycystic ovary syndrome, insulin resistance, idiopathic

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz)
An eruption of velvet warty benign growths and hyperpigmentation occurring in the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders, or obesity; a benign type occurs in children.
[L. fr. niger, black]

acanthosis nigricans

Black or brown pigmented warty areas overlying patches of ACANTHOSIS. These occur in the armpits and other body folds and may sometimes be associated with ACROMEGALY, ADDISON'S DISEASE, POLYCYSTIC OVARY, intestinal CANCER or the INSULIN RESISTANCE SYNDROME.

Acanthosis nigricans

A dark brownish or blackish discoloration of the skin related to overweight and high levels of insulin in the blood. Acanthosis nigricans is most likely to develop in the groin or armpits, or around the back of the neck.
Mentioned in: Insulin Resistance

Miescher,

Alfred Guido, Swiss dermatologist, 1877-1961.
Miescher cheilitis - Synonym(s): Melkersson-Rosenthal syndrome
Miescher-Leder syndrome - reddish granulomatous plaques. Synonym(s): granuloma disciformis; necrobiosis maculosa
Miescher I syndrome - benign velvety warty growths. Synonym(s): acanthosis nigricans
Miescher II syndrome - inflammatory granulomas of the lips. Synonym(s): granulomatous cheilitis

acanthosis nigricans 

A rare skin disorder presenting numerous superficial, pigmented papillomatous growths on various parts of the body. Ocular manifestations are primarily papillomatous lesions of the lid margins, which may be so extensive as to cause punctal occlusion, as well as papillary conjunctivitis. Syn. keratosis nigricans.

ac·an·tho·sis ni·gri·cans

(ak-an-thō'sis nī'gri-kanz) [MIM*100600]
Eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin.
[L. fr. niger, black]
References in periodicals archive ?
Table 3 Acanthosis nigricans at different body areas in patients with polycystic ovarian syndrome (n=50).
A quantitative scale of acanthosis nigricans. Diabetes Care.
Goran, "Relation between acanthosis nigricans and insulin sensitivity in overweight Hispanic children at risk for type 2 diabetes," Diabetes Care, vol.
In the vigorous exercise group, 24% had acanthosis nigricans, compared with 30% in the moderate exercise group and 40% in the inactive group.
Acanthosis nigricans and the sign of Leser-Trelat associated with adenocarcinoma of the gallbladder.
* Obesity-related conditions included asthma, depression, dyslipidemia, sleep apnea, diabetes, hypertension, tibia vara, acanthosis nigricans, steatohepatitis, dysmetabolic syndrome, and hyperinsulinemia.
The most common skin paraneoplastic manifestations are acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, paraneoplastic hypertrichosis lanuginosa acquisita, dermatomyositis, systemic sclerosis, and scleroderma [11-13].
Este instrumento colecta datos sobre antecedentes heredofamiliares de diabetes, edad del nino, sexo, IMC, estado de nutricion y presencia de acanthosis nigricans en cuello.
Besides PEO, DCS has also been observed in angio-immunoblastic lymphoma, (2) cutaneous Waldenstrom's macroglobulinemia, (3) acanthosis nigricans, (1,4) erysipelas, discoid lupus and acute contact dermatitis.
Hyperandogenism, insulin resistance and acanthosis nigricans syndrome: a common endocrinopathy with distinct pathophysiological features.
Clinical features vary from asymptomatic cases to oligomenorrhea/amenorrhea/irregular periods, subfertility, first trimester miscarriage, Obesity, Hirsutism, Acne12, Acanthosis nigricans and male pattern alopecia.3 Central obesity and acanthosis nigricans are signs of IR3 in PCOS and also increase the risk of type II diabetes mellitus by 5-10 times.13
Dark skin patches: A ring of dark skin at the back of the neck may be acanthosis nigricans, a condition in which the skin appears darker and thicker-even velvety-along body creases.