Incidental cutaneous reaction patterns: epidermolytic hyperkeratosis, acantholytic
dyskeratosis, and hailey-hailey-like acantholysis: a potential marker of premalignant skin change.
Dermatoses affecting desmosomes in animals: a mechanistic review of acantholytic
blistering skin diseases.
If the smears were positive for immunofluorescence the pattern of staining by the acantholytic
cells were noted.
Exfoliative toxins A and B are responsible for acantholytic
infection and serine proteases is resulted in epidermolysis (7).
Because of the recurrence of skin lesions without a fixed triggering factor, a skin biopsy was taken for histopathological and immunopathological examination, and erythema annulare-like acantholytic
dermatosis was suspected.
The presence of acantholytic
cells in the smear indicates but cannot confirm the diagnosis so it is not a specific test.4 DIF performed on the Tzanck smear indicating immunoglobulin deposits on the acantholytic
cells makes it a specific, inexpensive and easy diagnostic test for the diagnosis of pemphigus vulgaris.4,7 ORS of anagen hair is structurally similar to epidermis of skin.
Histology reveals groups of acantholytic
cells that resemble a "dilapidated brick wall." Direct immunofluorescence is negative, unlike pemphigus vulgaris.
Pemphigus vegetans (Pveg) is a rare variant of deep acantholytic
pemphigus which is mostly found in middle-age women patients.
Common presentations included pruritus, cutaneous eruptions, for example, maculopapular, eczematous, flare of Grover's disease (transient acantholytic
dermatosis), and less commonly vitiligo.
Histopathology of skin revealed exfoliative lesion with superficial acantholysis of epidermis along with acantholytic
process in external root sheath of the hair follicle and collection of neutrophils suggestive of Pemphigus foliaceus (Fig.
Most common subtype is the conventional squamous cell carcinoma, accounting for 90% of the cases, while other relatively common types are Verrucous carcinoma, Papillary squamous cell carcinoma, Basaloid squamous cell carcinoma, Acantholytic
squamous cell carcinoma, Spindle cell carcinoma and Adenosquamous carcinoma.7