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the presence in the blood of acanthocytes.
A rare condition in which the most of erythrocytes are acanthocytes; a regular feature of abetalipoproteinemia; also sometimes present in severe hepatocellular disease.
acanthocytosis(1) Abetalipoproteinemia, see there.
(2) A general term for the presence of acanthocytes in the peripheral blood.
Hereditary abetalipoproteinemia (hereditary acanthocytosis) accompanied by decreased total serum lipids, phospholipids, cholesterol, vitamin E, vitamin A; severe (end-stage) liver disease; hepatorenal failure; anorexia nervosa; chronic starvation. Small number of acanthocytes may be seen in severe haemolytic anaemia, especially post-splenectomy; haemolytic anaemia due to pyruvate kinase deficiency and intravascular mechanical defects (e.g., cardiac valve protheses, synthetic intravascular grafts and fibrin in DIC) in neonatal hepatitis after heparin administration; and rarely also in otherwise normal blood smears (one or 2 per smear), where they correspond to older, effete red cells approaching the end of their 120-day life-cycle.
1. Abetalipoproteinemia, see there.
2. A general term for the presence of acanthocytes in the peripheral blood. See Acanthocytes.
A rare condition in which most erythrocytes are acanthocytes; a regular finding in abetalipoproteinemia.