abundance mRNA

abundance mRNA

the amount of a specific mRNA in a CELL. mRNA of some GENES is produced in higher quantities than mRNA of other genes, depending upon how often the .gene is expressed. Cells from a particular TISSUE type or at different stages of DEVELOPMENT will have varying amounts of specific mRNA. Three abundance classes are identified in typical EUKARYOTE cells: high, medium and low abundance. See GENE EXPRESSION.
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These are all genes represented by high abundance mRNA, determined from the intensity of the fluorescence on the microarray (unpublished data).
First, CFTR mRNA is a low abundance mRNA, with ~0.1-1 copies per cell in the respiratory tract (1).
Therefore, the combination of reverse transcription with the high sensitivity of PCR has been increasingly applied to amplifying cDNA copies of low abundance mRNA. In particular, when combined with competitive internal DNA standards, this procedure is the method of choice for detecting and quantifying minimal amounts of mRNA transcripts (25-27).