abscopal

abscopal

 [ab-sko´p'l]
pertaining to the effect on nonirradiated tissue resulting from irradiation of other tissues of the body.

ab·sco·pal

(ab-skō'păl, -skop'ăl),
Denoting the effect that irradiation of a tissue has on remote nonirradiated tissue.
[ab- + G. skopos, target, + -al]

ab·sco·pal

(ab-skō'păl)
Denoting the effect that irradiation of a tissue has on remote nonirradiated tissue.
[ab- + G. skopos, target, + -al]

abscopal

Pertaining to a reaction in body tissue in an area outside an irradiated zone.

ab·sco·pal

(ab-skō'păl)
Denoting the effect that irradiation of a tissue has on remote nonirradiated tissue.
[ab- + G. skopos, target, + -al]
References in periodicals archive ?
The Journal of Medical Virology published a Targovax paper named 'Abscopal effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma'
It is the first demonstration following a bacterial cancer therapy of what is termed an 'abscopal' effect," Tal Danino, assistant professor of biomedical engineering, said.
Several patients have had shrinkage of non-injected tumors indicating an abscopal response.
The-37-year-old, who is from Akpugo in Nkanu West Local Government Area of Enugu State, won the award with his research work on 'Anti-PD-L1 Immunotherapy Enhances Radiation-induced Abscopal Response in Glioblastoma'.
"The early data from REVEAL demonstrate that a comprehensive approach to activating the body's immune system can drive abscopal anti-tumor responses even in the absence of a checkpoint inhibitor.
- Evaluate the abscopal response through the combination of NBTXR3 plus an anti-PD1 antibody and radiation therapy in specific and resistent murine lung cancer models, in order to measure NBTXR3's potential to control metastatic disease.
She said: "Promising pre-clinical data suggests that nanoparticles combined with radiotherapy enhance tumour-specific immune responses and lead to an abscopal response, priming a patient's immune system to attack cancer cells outside of the radiotherapy target area.
In addition to the chemotherapy treatment, the tumors outside the radiation field also decreased in size which could be either the effect of chemotherapy or the abscopal effect of radiation [18].
Intriguingly, immune checkpoint inhibitors exhibit a capacity to enhance the radiotherapy-triggered local immune response to systemic antitumor effects, that is, abscopal effects [79, 86, 87].
The role of these inflammatory molecules in the response of tissues to irradiation has also been related to the abscopal effect through adaptive immune responses [7].