The Journal of Medical Virology published a Targovax paper named 'Abscopal
effect when combining oncolytic adenovirus and checkpoint inhibitor in a humanized NOG mouse model of melanoma'
It is the first demonstration following a bacterial cancer therapy of what is termed an 'abscopal
' effect," Tal Danino, assistant professor of biomedical engineering, said.
Several patients have had shrinkage of non-injected tumors indicating an abscopal
The-37-year-old, who is from Akpugo in Nkanu West Local Government Area of Enugu State, won the award with his research work on 'Anti-PD-L1 Immunotherapy Enhances Radiation-induced Abscopal
Response in Glioblastoma'.
"The early data from REVEAL demonstrate that a comprehensive approach to activating the body's immune system can drive abscopal
anti-tumor responses even in the absence of a checkpoint inhibitor.
- Evaluate the abscopal
response through the combination of NBTXR3 plus an anti-PD1 antibody and radiation therapy in specific and resistent murine lung cancer models, in order to measure NBTXR3's potential to control metastatic disease.
(2012) Immunologic correlates of the abscopal
effect in a patient with melanoma.
She said: "Promising pre-clinical data suggests that nanoparticles combined with radiotherapy enhance tumour-specific immune responses and lead to an abscopal
response, priming a patient's immune system to attack cancer cells outside of the radiotherapy target area.
In addition to the chemotherapy treatment, the tumors outside the radiation field also decreased in size which could be either the effect of chemotherapy or the abscopal
effect of radiation .
The first hypothesis is the "abscopal
effect" of RT.
Intriguingly, immune checkpoint inhibitors exhibit a capacity to enhance the radiotherapy-triggered local immune response to systemic antitumor effects, that is, abscopal
effects [79, 86, 87].
The role of these inflammatory molecules in the response of tissues to irradiation has also been related to the abscopal
effect through adaptive immune responses .