Signaling different pathways of cell death: Abrin
induced programmed necrosis in U266B1 cells.
A toxin so potent as abrin
can be expected to have appeal as a murder weapon as well as a chemical warfare agent.
Different plant parts of this species contain various kinds of alkaloids such as glycerrhizin, precol, abrol, abrasine, abrins
(A and B) which impart its medicinal value (Joshi, S.G., 2000; Ghani, A., 2003).
Entry of the toxic proteins abrin
, modeccin, ricin, and diphtheria toxin into cells.
* Bruce Hammock and Ian Kennedy, University of California, Davis, to work on the development of miniaturized sensors for use in detecting botulinum toxin, ricin, and abrin
The herbal poison abrin
, extracted from precatory beans, is very similar to ricin.
Phytotoxin--A poisonous substance of plant origin; e.g., abrin
from rosary pea, Abrus precatorius; ricin from castor bean, Ricinus communis; crotin from croton, Codiaeum variegatum; and robin from black locust, Robinia pseudoacacia.
Mechanism of action of the toxic lectins abrin
The focus of phase I of this research contract will be on the development of biosensors for Abrin
Computer analysis showed that Ali, from Prescot Road, Old Swan, first began trawling the internet for information on poisons such as abrin
, ricin and cyanide in October last year.
The computer showed that Ali had begun searching Google in October last year for poisons such as abrin
, ricin and cyanide.
Type II RIP family is widely represented in plants of different taxonomic origins such as ricin, viscumin, abrin
, volkesin, etc.