aberrant crypt foci

aberrant crypt foci (colon)

A histopathological lesion which is regarded as the intermediate step between normal colonic epithelium and adenomatous growth.

Clinical findings
Patients may present with peptic-ulcer disease-like symptoms, nausea, vomiting, upper-GI bleeding; peak incidence is in middle-aged males (male:female ratio is 2:1).
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References in periodicals archive ?
APC mutations in aberrant crypt foci (ACF) and colonic tumors induced by azoximethane in F 344 rats.
The aim of this study was to investigate the influence of the administration of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitislike lesions in experimental colon cancer in rats.
The earliest hallmark for colon cancer is aberrant crypt foci (ACF).
The objective of scientists was to identify how strawberry leaf, raspberry leaf, hibiscus teas and cinnamon would affect azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.
CRC: Colorectal Carcinoma; CIN: Chromosome Instability; MSI: Microsatellite Instability; CIMP: CpG Island Methylator Phenotype; FAP: Familial Adenomatous Polyposis, HNPCC: Hereditary Nonpolyposis Colorectal Cancer; APC: Adenomatous Polyposis Coli; MMR: Mismatch Repair; ACF: Aberrant Crypt Foci
Another observation made was rats consuming dried plums had significantly reduced numbers of aberrant crypts, aberrant crypt foci and high-multiplicity aberrant crypt foci compared to control rats.
(15) In addition, BRAF mutations have been shown to occur early in the development of sporadic hyperplastic aberrant crypt foci in humans.
In the present study, CBD BDS significantly reduced the formation of aberrant crypt foci and polyps.
Bird, "Role of aberrant crypt foci in understanding the pathogenesis of colon cancer," Cancer Letters, vol.
The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.
These lesions are called 'aberrant crypt foci' and are considered to be good markers of colon cancer pathogenesis."