aberrant crypt foci

aberrant crypt foci (colon)

A histopathological lesion which is regarded as the intermediate step between normal colonic epithelium and adenomatous growth.

Clinical findings
Patients may present with peptic-ulcer disease-like symptoms, nausea, vomiting, upper-GI bleeding; peak incidence is in middle-aged males (male:female ratio is 2:1).

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References in periodicals archive ?

APC mutations in aberrant crypt foci (ACF) and colonic tumors induced by azoximethane in F 344 rats.

Distribucion de beta-catenina en lesiones displasicas de colon en ratas alimentadas con leche de bufala

The aim of this study was to investigate the influence of the administration of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitislike lesions in experimental colon cancer in rats.

Beneficial effect ofsynbiotics on experimental colon cancer in rats

The earliest hallmark for colon cancer is aberrant crypt foci (ACF).

An Appraisal of Pumpkin Seed Extract in 1, 2-Dimethylhydrazine Induced Colon Cancer in Wistar Rats

The objective of scientists was to identify how strawberry leaf, raspberry leaf, hibiscus teas and cinnamon would affect azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.

Executives. . .FYI

In addition, the earliest distinguishable neoplastic lesions in CRC models are aberrant crypt foci (ACF) [12].

Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-[beta]-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats

CRC: Colorectal Carcinoma; CIN: Chromosome Instability; MSI: Microsatellite Instability; CIMP: CpG Island Methylator Phenotype; FAP: Familial Adenomatous Polyposis, HNPCC: Hereditary Nonpolyposis Colorectal Cancer; APC: Adenomatous Polyposis Coli; MMR: Mismatch Repair; ACF: Aberrant Crypt Foci

Anticancer activities of resveratrol in colorectal cancer

Another observation made was rats consuming dried plums had significantly reduced numbers of aberrant crypts, aberrant crypt foci and high-multiplicity aberrant crypt foci compared to control rats.

Dried Plums Can Reduce Risk of Colon Cancer

(15) In addition, BRAF mutations have been shown to occur early in the development of sporadic hyperplastic aberrant crypt foci in humans.

Molecular and Histologic Considerations in the Assessment of Serrated Polyps

In the present study, CBD BDS significantly reduced the formation of aberrant crypt foci and polyps.

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

Bird, "Role of aberrant crypt foci in understanding the pathogenesis of colon cancer," Cancer Letters, vol.

Evaluation of blueberry juice in mouse azoxymethane-induced aberrant crypts and oxidative damage

The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.

Effects of chitosan on body weight gain, growth hormone and intestinal morphology in weaned pigs

These lesions are called 'aberrant crypt foci' and are considered to be good markers of colon cancer pathogenesis."