aberrant crypt foci

aberrant crypt foci (colon)

A histopathological lesion which is regarded as the intermediate step between normal colonic epithelium and adenomatous growth.

Clinical findings
Patients may present with peptic-ulcer disease-like symptoms, nausea, vomiting, upper-GI bleeding; peak incidence is in middle-aged males (male:female ratio is 2:1).

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References in periodicals archive ?

The objective of scientists was to identify how strawberry leaf, raspberry leaf, hibiscus teas and cinnamon would affect azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats.

Executives. . .FYI

CRC: Colorectal Carcinoma; CIN: Chromosome Instability; MSI: Microsatellite Instability; CIMP: CpG Island Methylator Phenotype; FAP: Familial Adenomatous Polyposis, HNPCC: Hereditary Nonpolyposis Colorectal Cancer; APC: Adenomatous Polyposis Coli; MMR: Mismatch Repair; ACF: Aberrant Crypt Foci

Anticancer activities of resveratrol in colorectal cancer

The first identifiable changes in CRC carcinogenesis are aberrant crypt foci (ACF).

Chromoendoscopy with a standard-resolution colonoscope for evaluation of rectal aberrant crypt foci

Another observation made was rats consuming dried plums had significantly reduced numbers of aberrant crypts, aberrant crypt foci and high-multiplicity aberrant crypt foci compared to control rats.

Dried Plums Can Reduce Risk of Colon Cancer

15) In addition, BRAF mutations have been shown to occur early in the development of sporadic hyperplastic aberrant crypt foci in humans.

Molecular and Histologic Considerations in the Assessment of Serrated Polyps

Based on our laboratory experience, this time (at the dose of AOM used) was associated with the occurrence of a significant number of aberrant crypt foci (ACF), polyps and tumours.

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

The influence of high and low molecular weight chitosan on colonic cell proliferation and aberrant crypt foci development in CF1 mice.

Effects of chitosan on body weight gain, growth hormone and intestinal morphology in weaned pigs

They are also described as aberrant crypt foci (ACF) (22).

Disminucion de lesiones displasicas colonicas inducidas por 1,2-dimetilhidrazina en ratas suplementadas con acido butirico

Kunihiro Hosono of the Yokohama City University School of Medicine, Japan, and colleagues wrote, "This first reported trial of metformin for inhibiting colorectal carcinogenesis in humans provides preliminary evidence that metformin suppresses colonic epithelial proliferation and rectal aberrant crypt foci, suggesting its promise for the chemoprevention of colorectal cancer" (Cancer Prev.

Metformin shows cancer-prevention potential

A comparison of the capacity of different fibres to increase butyrate production confirmed that only fibres promoting stable butyrate production in the colon, such as scFOS, are likely to have an effect on the development of colorectal cancer in rats--by reducing the number of aberrant crypt foci, considered as precancerous lesions of the colonic epithelium.

Prebiotic fibres: a natural source of cancer prevention

BRAF mutations in the aberrant crypt foci and hyperplastic polyposis.

Improved marker combination for detection of de novo genetic variation and aberrant DNA in colorectal neoplasia

Carrageenan given as a jelly, does not initiate, but promotes the growth of aberrant crypt foci in the rat colon.