abacavir


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abacavir

 [ah-bak´ah-vir]
a non-nucleoside reverse transcriptase inhibitor used as an antiretroviral in treatment of human immunodeficiency virus infection; administered orally as the sulfate salt.

abacavir

(ə-băk′ə-vîr′)
n.
An antiviral drug, C14H18N6O, that is a nucleoside reverse transcriptor inhibitor and is used in its sulfate form in combination with other drugs for the treatment of HIV infection.

abacavir

An HIV-nucleoside reverse-transcriptase inhibitor (NRTI/integrase inhibitor) similar to AZT.
 
Adverse effects
Life-threatening allergic reactions—fever, dyspnea, rashes, intraoral blistering, nausea, headache.

abacavir

Ziagen, zintavir, 1592 AIDS An HIV nucleoside reverse transcriptase inhibitor–NRTI/integrase inhibitor similar to AZT Adverse effects Life-threatening allergic reactions–fever, dyspnea, rashes, intraoral blistering, nausea, headache. See AIDS, Nucleoside reverse transcriptase inhibitor, Reverse transcriptase.

abacavir

A nucleoside reverse transcriptase inhibitor drug used in combination with other anti-HIV drugs to treat AIDS. A brand name is Ziagen. In combination with lamivudine and zidovodine it is marketed as Trizivir.
References in periodicals archive ?
Among 200 patients with HIV treated with abacavir, the 13 with a particular constellation of three gene variants within the complex all developed an allergic reaction to the drug, says Simon Mallal of the Centre for Clinical Immunology and Biomedical Statistics at Royal Perth Hospital in Australia.
Use of abacavir in 30 HIV-infected children from Durban, South Africa: report from a pilot study.
universities found improvements in lipoatrophy when d4T was replaced by either AZT or abacavir. Of 118 volunteers enrolled, 86 switched to abacavir, the others to AZT (as Combivir).
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI).
The mechanisms of abacavir hypersensitivity is better studied compared to other drug-induced ADRs.
HLA-B*5701 screening for hypersensitivity to abacavir. N Engl J Med.
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction J Antimicrob Chemother.
One meta-analysis of recent observational studies determined that recent abacavir or protease inhibitor use approximately doubled chances of myocardial infarction.
Group A received a non-nucleoside reverse transcriptase inhibitor (NNRTI), lamivudine, and abacavir. Groups B and C received an NNRTI, lamivudine, abacavir, and zidovudine therapy; after week 36, the regimen was reduced to a three-drug NNRTI, lamivudine plus abacavir in group B and lamivudine, abacavir plus zidovudine in group C.
For docking validation, redocking was performed using the recently published X-ray structure of the complex between an anti-HIV drug abacavir and the HLA-B x 57:01 molecule [10].
Recently, the detailed molecular mechanism underlying the strong association between HLA-B* 57 and the hypersensitivity of reverse-transcriptase inhibitor abacavir has been disclosed [5].
Whereas lamivudine tablets may be divided and, if necessary, crushed for easier ingestion by younger children, currently available abacavir tablets are film-coated and unscored and must be swallowed whole.