Among 200 patients with HIV treated with abacavir
, the 13 with a particular constellation of three gene variants within the complex all developed an allergic reaction to the drug, says Simon Mallal of the Centre for Clinical Immunology and Biomedical Statistics at Royal Perth Hospital in Australia.
Use of abacavir
in 30 HIV-infected children from Durban, South Africa: report from a pilot study.
universities found improvements in lipoatrophy when d4T was replaced by either AZT or abacavir
. Of 118 volunteers enrolled, 86 switched to abacavir
, the others to AZT (as Combivir).
is a nucleoside reverse transcriptase inhibitor (NRTI).
The mechanisms of abacavir
hypersensitivity is better studied compared to other drug-induced ADRs.
HLA-B*5701 screening for hypersensitivity to abacavir
. N Engl J Med.
The purine analogues abacavir
and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction J Antimicrob Chemother.
One meta-analysis of recent observational studies determined that recent abacavir
or protease inhibitor use approximately doubled chances of myocardial infarction.
Group A received a non-nucleoside reverse transcriptase inhibitor (NNRTI), lamivudine, and abacavir
. Groups B and C received an NNRTI, lamivudine, abacavir
, and zidovudine therapy; after week 36, the regimen was reduced to a three-drug NNRTI, lamivudine plus abacavir
in group B and lamivudine, abacavir
plus zidovudine in group C.
For docking validation, redocking was performed using the recently published X-ray structure of the complex between an anti-HIV drug abacavir
and the HLA-B x 57:01 molecule .
Recently, the detailed molecular mechanism underlying the strong association between HLA-B* 57 and the hypersensitivity of reverse-transcriptase inhibitor abacavir
has been disclosed .
Whereas lamivudine tablets may be divided and, if necessary, crushed for easier ingestion by younger children, currently available abacavir
tablets are film-coated and unscored and must be swallowed whole.