alpha1-antitrypsin

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α1-an·ti·tryp·sin

A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. The concentration of α1-antitrypsin increases in response to injury or infection. α1-Antitrypsin also inhibits thrombin and elastase.

alpha1-antitrypsin

/al·pha1-an·ti·tryp·sin/ (-an″tĭ-trip´sin) a plasma α1-globulin produced primarily in the liver; it inhibits the activity of elastase, cathepsin G, trypsin, and other proteolytic enzymes. Deficiency is associated with development of emphysema.

α1-antitrypsin

/α1-an·ti·tryp·sin/ (-trip´sin) alpha.

alpha1-antitrypsin

Etymology: Gk, anti, against, trypsin
a plasma protein produced in the liver that inhibits the action of proteolytic enzymes such as trypsin. Deficiencies are associated with liver disease in children and panacinar emphysema in adults. In the latter, the basic lesion is believed to result from effects of proteolytic enzymes on the walls of the alveoli. Also called antitrypsin, alpha1-proteinase inhibitor.

α1-an·ti·tryp·sin

(an'tē-trip'sin)
A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein.

alpha1-antitrypsin

a plasma protein (α1-globulin) produced in the liver, which inhibits the activity of trypsin and other proteolytic enzymes. Deficiency of this protein is associated with round heart disease in turkeys. Called also α1-protease inhibitor.

alpha1-antitrypsin mastitis test
after the first month of lactation, it is an indication of leakage through damaged endothelium.
References in periodicals archive ?
Polyclonal affinity-purified antibodies specific for human proteins IL-6, IL-8, IgA-uromodulin complex, MCP-1, EGF, a1-antitrypsin, LG3 fragment of endorepellin, soluble transferrin receptor, tumstatin, and endostatin were obtained from Antibody Technology Inc.
4] Proteomic markers a1-Antitrypsin IgA-Uromodulin Galactose-deficient IgA1 Heparan sulfate
The differential diagnosis of bullous lung disease includes tobacco smoking, intravenous drug use (methyphenidate, heroin, cocaine), marijuana and cocaine smoking, and a long list of diseases including a1-antitrypsin deficiency, HIV infection, auto-immune and connective tissue disorders, bullous sarcoidosis, idiopathic giant bullous emphysema and neurofibromatosis.
The liver scarring of a1-antitrypsin (AT) deficiency, the most common genetic cause for liver transplantation, can be treated with Tegretol or carbamazepine, according to findings from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.
Background: As an acute phase protein, a1-antitrypsin (AAT) has been extensively studied in acute coronary syndrome, but it is unclear whether a relationship exists between AAT and stable angina pectoris (SAP).
a1-antitrypsin (AAT) is an acute phase protein that is mainly produced in the liver.
Thus, it is generally assumed that the sum of f-PSA plus ACT-PSA yields t-PSA, whereas the small amounts of PSA being bound to other proteins such as a1-antitrypsin and protein C may be neglected.
Stability of albumin, protein HC, immunoglobulin G, ic- and A-chain immunoreactivity, orosomucoid and a1-antitrypsin in urine stored at various conditions.