alpha1-antitrypsin

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α1-an·ti·tryp·sin

A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein. The concentration of α1-antitrypsin increases in response to injury or infection. α1-Antitrypsin also inhibits thrombin and elastase.

α1-an·ti·tryp·sin

(an'tē-trip'sin)
A glycoprotein that is the major protease inhibitor of human serum, is synthesized in the liver, and is genetically polymorphic due to the presence of 25 alleles; people appropriately homozygous are deficient in α1-trypsin and are predisposed to pulmonary emphysema and juvenile hepatic cirrhosis because of alterations in the amino acid and sialic acid components of the glycoprotein.
References in periodicals archive ?
A set of reagents for the quantitative determination of a1-antitrypsin; To determine antitrypsin, Glycated hemoglobin; To determine hemoglobin, Glycohemoglobin calibrator; To calibrate glycohemoglobin, Glycosylated hemoglobin (type 1) is the norm; For quality control, Glycosylated hemoglobin (type 2) pathology; For quality control
Variable GRF Saliva Age 0.16 (0.22) 0.04 (0.73) Male gender 0.12 (0.36) -0.03 (0.80) Prevalence of PD [greater than or 0.36 (<0.01 **) 0.46 (<0.01 **) equal to] 4 mm BOP 0.42 (<0.01 **) 0.50 (<0.01 **) a1-antitrypsin in saliva 0.53 (<0.01 **) -- PD: probing pocket depth, BOP: bleeding on probing, GRF: gingival retention fluid.
Arindkar et al., "Bone marrow stem cell therapy partially ameliorates pathological consequences in livers of mice expressing mutant human a1-antitrypsin," Hepatology, vol.
The patient was tested for a1-antitrypsin deficiency, which was normal with the phenotype being [M.sub.2] [M.sub.2].
Kallistatin belongs to the serpin family, which includes a1-antitrypsin and a1-antichymotrypsin [2].
The differential diagnosis of bullous lung disease includes tobacco smoking, intravenous drug use (methyphenidate, heroin, cocaine), marijuana and cocaine smoking, and a long list of diseases including a1-antitrypsin deficiency, HIV infection, auto-immune and connective tissue disorders, bullous sarcoidosis, idiopathic giant bullous emphysema and neurofibromatosis.
The liver scarring of a1-antitrypsin (AT) deficiency, the most common genetic cause for liver transplantation, can be treated with Tegretol or carbamazepine, according to findings from Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.
Longitudinal changes in physiological, radiological, and health status measurements in a1-antitrypsin deficiency and factors associated with decline.
By contrast, the protein expression level of a1-antitrypsin, haptoglobin, and transthyretin was remarkably reduced in ALI plasma.
Polyclonal affinity-purified antibodies specific for human proteins IL-6, IL-8, IgA-uromodulin complex, MCP-1, EGF, a1-antitrypsin, LG3 fragment of endorepellin, soluble transferrin receptor, tumstatin, and endostatin were obtained from Antibody Technology Inc.