alpha-ketoglutarate dehydrogenase

(redirected from a-ketoglutarate dehydrogenase)

α-ke·to·glu·tar·ate de·hy·dro·gen·ase

an enzyme that catalyzes the oxidative decarboxylation of 2-ketoglutaric acid to succinyldihydrolipoate; the succinyl group is later transferred to CoA and the reduced lipoate is oxidized by NAD+; a complex that is a part of the tricarboxylic acid cycle.
References in periodicals archive ?
The activities of hepatic mitochondrial enzymes such as isocitrate dehydrogenase (ICH) a-ketoglutarate dehydrogenase (KDH) succinate dehydrogenase (SH) malate dehydrogenase (MDH) NADPH dehydrogenase and cytochrome C oxidase were significantly decreased in CCl4- hepatotoxic rats and administration of corosolic acid brought back these parameters towards normal.
a-ketoglutarate dehydrogenase was assayed by the method of Reed and Mukherjee (1969) a standard containing potassium ferrocyanide was assayed simultaneously.
Thiamine and its dependent enzymes, transketolase (TK), pyruvate dehydrogenase, a-ketoglutarate dehydrogenase and the branched chain a-ketoglutarate dehydrogenase complex are involved in the maintenance of NADPH levels and carbohydrate metabolism in the cell8.