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A highly toxic, heat-stable bicyclic oligopeptide in the mushroom Amanita phalloides. It inhibits transcription by certain RNA polymerases.
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References in periodicals archive ?
The contract has been signed in an effort to develop a novel class of antibody drug conjugates that will be based on Heidelberg Pharma's patented technology to integrate a-Amanitin to antibodies.
The death cap mushroom, which resembles the common white button mushroom, contains one of the most deadly poisons found in nature, a-amanitin.
In vivo degradation of RNA polymerase II largest subunit triggered by a-amanitin. Nucleic Acids Res 1996;24:2924-9.