alpha-amanitin

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α-am·a·ni·tin

(am-ă-nī'tin),

A highly toxic, heat-stable bicyclic oligopeptide in the mushroom Amanita phalloides. It inhibits transcription by certain RNA polymerases.

References in periodicals archive ?

The contract has been signed in an effort to develop a novel class of antibody drug conjugates that will be based on Heidelberg Pharma's patented technology to integrate a-Amanitin to antibodies.

Heidelberg Pharma signs licensing agreement with Roche

The death cap mushroom, which resembles the common white button mushroom, contains one of the most deadly poisons found in nature, a-amanitin.

Death cap mushroom poison shows promise to arrest pancreatic cancer

In vivo degradation of RNA polymerase II largest subunit triggered by a-amanitin. Nucleic Acids Res 1996;24:2924-9.

Quantification of gp350/220 Epstein-Barr Virus (EBV) mRNA by real-time reverse transcription-PCR in EBV-associated diseases