alpha-adrenergic receptors

(redirected from a-adrenergic receptors)

α-ad·re·ner·gic re·cep·tors

adrenergic receptors in effector tissues capable of selective activation and blockade by drugs; conceptually derived from the ability of certain agents, such as phenoxybenzamine, to block only some adrenergic receptors and of other agents, such as methoxamine, to activate only the same adrenergic receptors. Such receptors are designated as α-receptors. Their activation results in physiologic responses such as increased peripheral vascular resistance, mydriasis, and contraction of pilomotor muscles.

α-ad·re·ner·gic re·cep·tors

(adrĕ-nĕrjik rĕ-septŏrz)
Those in effector tissues capable of selective activation and blockade by drugs; conceptually derived from the ability of certain agents, such as phenoxybenzamine, to block only some adrenergic receptors and of other agents, such as methoxamine, to activate only the same adrenergic receptors. Such receptors are designated as α-receptors. Their activation results in physiologic responses such as increased peripheral vascular resistance, mydriasis, and contraction of pilomotor muscles.
References in periodicals archive ?
These adrenergic receptors (ADRs) encoded by the ADRA (a-adrenergic receptors - inhibitory) and ADRB ([beta]-adrenergic receptors - stimulatory) genes are part of the sympathetic nervous system and exert their actions via coupling with the catecholamines.
Alpha-blockers reduce flank pain by causing a decrease in the muscle tone of the ureter, trigone of the bladder and prostatic urethra by means of blocking the a-adrenergic receptors and thereby decreasing the bladder outlet resistance and the pressure developed during micturition.
Aconite contains noradrenaline salsolinol, which has excitatory effects on p receptors and a-adrenergic receptors, which can significantly increase cerebral blood flow by improving mean arterial pressure (MAP) [8].
Asenapine binds to several serotonergic, dopaminergic, and a-adrenergic receptors, but has almost no affinity for muscarinic cholinergic receptors, and so is assumed to cause fewer significant anticholinergic side effects, compared with other antipsychotic medications.