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An F-actin binding protein in vertebrate cells that cross-links actin filaments into regular parallel arrays. It is found in both the Z line and the I band of striated muscle.
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Positive staining of cardiac markers sarcomeric a-actinin and Nkx2.
After 24 h, very small percentages of the cells treated with the extract and chromatin-modifying agents reacted with a-actinin and myosin heavy chain (2.
After 10 days, the extract-treated cells were able to express a-actinin and myosin heavy chain, but not the other markers.