This synapse is formed between the axon terminal (
presynaptic neuron) sending information and the neuron dendrite (postsynaptic neuron) receiving information.
Syntaxin 1A protein is located in the
presynaptic region and forms the SNARE complex with SNAP-25 and VAMP2; the SNARE complex is critical in neurotransmission (14).
Where the Ac was an area occupied by clustered synaptic vesicles and At indicated the area of the
presynaptic terminal, respectively.
Additionally atropine and scopolamine had showed 10 times higher affinity for
presynaptic receptors than postsynaptic receptors (16).
schneideri poison, indicating that this poison seems to act mainly at
presynaptic site, including in motor innervation.
Neuronal synapses are highly enriched with mitochondria in order to fulfill the high energy requirements needed to fuel the active processes required for synaptic transmission, producing the ATP needed to maintain synaptic ion homeostasis and phosphorylation reactions in
presynaptic terminals [10-12].
The duration of TCA treatment should also be considered.[14] In short-term TCA treatment, patients can respond to indirect-acting sympathomimetics such as ephedrine due to increased
presynaptic availability of norepinephrine.
The analysis of central synapses often stimulated
presynaptic axons and recorded postsynaptic responses.
In this study, we aimed to extend this knowledge and study the role of striatal
presynaptic proteins, with regard to the quantitative changes in their levels, in LID pathogenesis.
As the dose increases, lumateperone also serves as a mesolimbic and mesocortical dopamine receptor phosphoprotein modulator with dual properties, acting at the level of the dopamine D2 receptor both as a
presynaptic partial agonist and a postsynaptic antagonist.