NUMEROUS KERATIN PEARLS AND FEW MITOTIC FIGURES WITH CELLULAR AND NUCLEAR PLEOMORPHISM AND
HYPERCHROMATISM WEREALSO SEEN, ADIAGNOSIS OF WELL-DIFFERENTIATED SQUAMOUS CELL CARCINOMA WAS GIVE (H&E 20X).
Osteosarcoma contains numerous giant cells but displays far more cellular pleomorphism,
hyperchromatism, and a variety of other cells often of indeterminate appearance [14].
Three cases showed focal atypia as basilar hyperplasia and
hyperchromatism. The connective tissue revealed marked hyperemia.
The endothelial cells that lining these channels display
hyperchromatism and pleomorphism, have round or oval aspect, sometimes protuberant (Figures 7 and 8).
(57-59) Cells and nuclei take on more primitive appearance, similar to those of basal cells with enlarged nuclei (nuclear hyperplasia), dark-staining nuclei (
hyperchromatism), often enlarged eosinophilic nucleoli (prominent nucleoli) and with increased nuclear-to-cytoplasmic ratio.
There might be slight
hyperchromatism, but chromatin is uniformly and finely granulated and free of major chromatin abnormalities (figure 2).
Thus, were observed damage of total architectonics of liver, microcirculation disturbances, cellular polymorphism, destruction of border plane; incompletion of hepatocytes, fat, hydropic and balloon dystrophy of hepatocytes, lipofuscinosis of hepatocytes, nidus hepatonecrosis,
hyperchromatism and polychromatism, degeneration (vacuolization) of hepatocytes' nuclei, intralobular lymphoplasmocytic infiltration, pericentral lymphoid infiltration.
(7) The criteria of atypia included the presence of the major malignant features including; nuclear enlargement associated with increased nuclear cytoplasmic ratio,
hyperchromatism, chromatin clumping with moderately prominent nucleolation and irregular nuclear borders, bi or multinuclation, and scantiness of the cytoplasm and variations in size and/or shape of the cells and nuclei.
A juxtacortical chondroma must be differentiated from a juxtacortical (or periosteal) chondrosarcoma, particularly as a juxtacortical chondroma often demonstrates high cellularity, binucleated cells,
hyperchromatism and a myxoid appearance.
On histologic analysis, unlike in leiomyosarcomas, the absence of mitotic figures, pleomorphism and
hyperchromatism are the usual features.[sup.12,13] Importantly, any evidence of invasion usually indicates a malignant leiomyosarcoma.[sup.12]-[sup.14]
It can also be seen in some of these islands the presence of squamous metaplasia, peripheral cells arranged in palisade exhibiting
hyperchromatism and cores of reverse polarity.