glomerulosclerosis

[glo-mer″u-lo-sklĕ-ro´sis]

diabetic glomerulosclerosis (intercapillary glomerulosclerosis) a degenerative complication of diabetes mellitus in which there is glomerular mesangial expansion with either diffuse lesions or nodular (Kimmelstiel-Wilson) lesions; symptoms include albuminuria, nephrotic edema, hypertension, renal insufficiency, and retinopathy. The type with nodular lesions is also called Kimmelstiel-Wilson syndrome.

focal segmental glomerulosclerosis focal sclerosing lesions of the renal glomeruli, with proteinuria, hematuria, hypertension, and the nephrotic syndrome; it may be idiopathic or secondary to another condition. Called also focal glomerular sclerosis.

glo·mer·u·lo·scle·ro·sis

(glō-mer'yū-lō-sklē-rō'sis),

Hyaline deposits or scarring within the renal glomeruli, a degenerative process occurring in association with renal arteriosclerosis or diabetes.

Synonym(s): glomerular sclerosis

[glomerulus + G. sklērōsis, hardness]

Farlex Partner Medical Dictionary © Farlex 2012

glomerulosclerosis

Nephrology A degenerative lesion of the renal glomeruli caused by ASHD or DM. See Kimmelsteil-Wilson disease.

glo·mer·u·lo·scle·ro·sis

(glō-mer'yū-lō-skler-ō'sis)

Hyaline deposits or scarring within the renal glomeruli, a degenerative process occurring in association with renal arteriosclerosis or diabetes mellitus.

[glomerulus + G. sklērōsis, hardness]

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

glomerulosclerosis

A kidney disease in which many glomeruli (see GLOMERULUS), previously damaged by inadequate blood supply or GLOMERULONEPHRITIS, become replaced by a non-functioning glassy (hyaline) material. It sometimes occurs without prior damage. The effects resemble those of the NEPHROTIC SYNDROME and kidney function gradually deteriorates. Kidney failure is a common outcome.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 2000;24:251-6.

New Mutation of Coenzyme Q[sub]10 Monooxygenase 6 Causing Podocyte Injury in a Focal Segmental Glomerulosclerosis Patient

Focal and segmental glomerulosclerosis: definition and relevance of a partial remission.

EFFECTIVENESS OF IMMUNOSUPPRESSANTS ALONG WITH ACEI/ARBS IN TREATING PROTEINURIA IN PATIENTS WITH SOLITARY KIDNEY POST NEPHRECTOMY

These patients were on the tenofovir based regimen, the biopsy revealed interstitial nephritis with glomerulosclerosis which could be due to TDF.

ACUTE KIDNEY INJURY AND CHRONIC KIDNEY DISEASE IN HIV PATIENTS IN THE ERA OF ANTIRETROVIRAL THERAPY

Wei et al., "Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis," Science Translational Medicine, vol.

Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation

Kalluri, "Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors," Diabetes, vol.

Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease

Vincenti, "Recurrent focal glomerulosclerosis: natural history and response to therapy," American Journal of Medicine, vol.

Preoperative Low-Density Lipoprotein Apheresis for Preventing Recurrence of Focal Segmental Glomerulosclerosis after Kidney Transplantation

Interestingly, this patient showed typical features of hepatic glomerulosclerosis, including chronic sclerotic and fibrotic changes, upon histological examination.

A Case of Hepatic Glomerulosclerosis with Monoclonal IgA1-[kappa] Deposits

It showed that in 100 patients who developed renal disease whilst on anti-VEGF treatment, the main histology associated with TKIs was minimal change disease and/or collapsing-like focal segmental glomerulosclerosis (MCN/cFSGS), a FSGC variant which is considered a separate entity to FSGS.

A Case of Lenvatinib-Induced Focal Segmental Glomerulosclerosis (FSGS) in Metastatic Medullary Thyroid Cancer

Abbreviations EPS: Encapsulating peritoneal sclerosis PD: Peritoneal dialysis ESRD: End-stage renal disease HD: Hemodialysis LOA: Lysis of adhesions OSH: Outside hospital SBO: Small bowel obstruction TPN: Total parenteral nutrition NGT: Nasogastric tube FSGS: Focal segmental glomerulosclerosis POD: Postoperative day.

Surgical Management of Encapsulating Peritoneal Sclerosis: A Case Report in Kidney Transplant Patient

Effect of various histological changes on graft function at 1 month Histological changes if Number of Effect on graft function cortical biopsy patients (out of 84) Normal histology 48 (58%) No effect Glomerulosclerosis 21 (25%) No effect Interstitial fibrosis 11 (13%) Delayed graft function: 4 Acute tubular necrosis 4 (5%) Acute rejection: 2 Delayed graft function: 2 Focal tubal atrophy 4 (5%) No effect Table 2.

Can zero-hour cortical biopsy predict early graft outcomes after living donor renal transplantation?

Canada-based Aurinia Pharmaceuticals is planning to expand its voclosoprin renal franchise to include focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD), it was reported on Monday.

Aurinia Pharmaceuticals plans to expand voclosoprin renal franchise

This might give the team insight into how to counter the effects of congenital gene mutations that can cause glomerulosclerosis, another common cause of kidney failure.

Mini-Kidneys Grown in Lab Reveal Renal Disease Secrets