Plasma samples collected for possible
aprepitant assay and urine samples for possible tolbutamide/metabolite assays were archived by the Department of Drug Metabolism, Merck Research Laboratories (MRL), West Point, PA, as it was determined by the Clinical Pharmacology and Drug Metabolism departments of MRL that it would not be necessary to assay these samples.
Aprepitant comes in both oral and injectable formulations.
Aprepitant Capsules will be made available in the US in dosages of 40 mg, 80 mg and 125 mg.
Aprepitant is approved for 3 days of use only for its licensed indication.
The product is a proprietary intravenous formulation of
aprepitant, a NK1 receptor antagonist intended for the prevention of CINV.
Aprepitant (Emend) is approved as an antiemetic agent for cancer patients on chemotherapy.
To prevent delayed emesis in patients receiving cisplatin and other high emetic risk agents, dexamethasone and
aprepitant is recommended on day 2 and 3 as well.
Emend (
aprepitant) is approved for use in combination with other antivomiting medicines to help prevent the acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy.
The company stated that CINVANTI (HTX-019) is the first polysorbate 80-free, intravenous formulation of
aprepitant for the prevention of CINV.
Some data also support the off-label use of the neurokinin-1 receptor antagonist
aprepitant as an acute and preventive treatment, she said.