It varied considerably in the temporal
allocortex, and occurred at low levels in the neocortex.
From this perspective the topological center of the forebrain is not the thalamus but the entorhinal cortex, which was the first six-layered neocortex to emerge at "TA" from the three-layered primitive
allocortex. Neocortex with its potential for avast surface area expanded the arms race and the importance of consciousness as the weapon of choice.
Intraventricular administration of Al-maltolate to rabbits developed widespread neurofibrillary degeneration involving pyramidal neurons of the isocortex and
allocortex, projection neurons of the diencephalon, and nerve cells of the brain stem and spinal cord (37).