CYP3A5, ABCB1 and
SLCO1B1 Polymorphisms and Pharmacokinetics and Virologic Outcome of Lopinavir/Ritonavir in HIV-infected Children.
The human organic anion transporting polypeptide 1B1 (OATP1B1) (gene symbol
SLCO1B1, previously OaTP2, OATP-C, and LST-1) [4] is expressed solely on the basolateral membrane of hepatocytes, facilitating the uptake of clinically relevant compounds such as antibacterial drugs, statins, and chemotherapeutic drugs [5].
Solute carrier organic anion transporter family member 1B1 (
SLCO1B1) is one of the organic anion transporters and localized at the sinusoidal membrane of hepatocytes, and its transcript has been detected in enterocytes.
2007), we demonstrated that transfection of OATP1B1 (
SLCO1B1) or OATP1B3 (SLCO1B3) cDNA into HEK293 cells increased their sensitivity to, and their accumulation of, microcystin-LR and, consequently, induced apoptosis in those cells.
(34.) SEARCH Collaborative Group,
SLCO1B1 Variants and Statin Induced Myopathy--A Genomewide Study, 359 NEW ENG.
Genomewide association studies showed a strong correlation with a variant form of the gene
SLCO1B1. The risk of myopathy was 18% among homozygotes for the high-risk allele and 2% for heterozygotes (one copy of the high-risk and one copy of the low-risk allele).
They found a strong association of myopathy with single-nucleotide polymorphism located within the
SLCO1B1 gene.
As the role of
SLCO1B1 gene (encodes OATP1B1 or liver specific transporter-1) 388 A>G polymorphism in susceptibility towards gallstone disease is unclear the prevalence of this polymorphism in healthy north Indian population was investigated.
A variant form of the gene
SLCO1B1 may be responsible for muscle pain that statins sometimes cause (SN: 8/16/08, p.