CACNG3

A gene on chromosome 16p12.1 that encodes a gamma subunit of a voltage-dependent calcium channel, which regulates AMPA-selective glutamate receptor (AMPAR) trafficking and gating. It promotes
AMPAR targeting to the cell membrane and synapses, and it modulates their gating properties by slowing their activation, deactivation and desensitisation.

References in periodicals archive

Four of them--HPCA, CACNG3, CA10, PLPPR4--were repressed and one overexpressed CRYAB.

In the repressed genes network (figure 4A) four hub genes were identified: hypocalcin (HPCA), calcium voltage-gated channel auxiliary subunit gamma 3 (CACNG3), carbonic anhydrase-related protein 10 (CA10), and phospholipid phosphatase related 4 protein (PLPPR4).

Linkage and association analysis of CACNG3 in childhood absence epilepsy.

Analisis de redes de coexpresion identifica posibles genes clave en el envejecimiento de la corteza prefrontal humana

Additionally, they identified several genes related to glutamate (including CACNG3, a regulator of AMPA-sensitive glutamate receptors; SLC17A7, a mitochondrial oxo-glutarate carrier; and GOT2, mitochondrial glutamic-oxaloacetic transaminase.

Exploring Potential Biomarkers Underlying Pathogenesis of Alzheimer's Disease by Differential Co-expression Analysis

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